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Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression

Treatment Resistant Depression Clinical Trial

Official title:
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression

Clinical Trial Summary

Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients. The most frequently considered surgical approach is deep brain stimulation (DBS) of a part of the brain called the subcallosal cingulate region. However, the effectiveness and safety is not well established. The investigators will use a novel approach using advanced imaging technique (magnetic resonance tractography) to evaluate the feasibility and safety of this surgical approach. An innovative method for the definition of DBS target will be applied that redefines the concept of targeting as one of targeting a symptomatic network rather than a structural brain region using subject-based brain anatomy to define the target location. The correlation between imaging findings at baseline with the mood score changes at different time points of the study will be investigated.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03952962
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Nader Pouratian, MD, PhD
Phone 310/274-2095
Email Nader.Pouratian@UTSouthwestern.edu
Status Recruiting
Phase N/A
Start date October 28, 2022
Completion date July 2025
View Details
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