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Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression — MAOI  

Treatment Resistant Depression Clinical Trial

Official title:
Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression

Clinical Trial Summary

Study TRD subjects' resistance to at least 2 different antidepressants, we hypothesize that because of their significant depression and treatment resistant status they are most likely to exhibit BSMN pathway abnormalities.

Clinical Trial Description

Potential subjects will be identified during clinical visits. If a patient qualifies to participate in the study they will have to stop any antidepressants that they are taking to prepare for the use of MAOIs. After a two week washout period, subjects will have an fMRI and will be started on a MAOI. They will then be followed up for 8 weeks, which is routine and considered standard care. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03109717
Study type Observational
Source The Cleveland Clinic
Contact
Status Completed
Phase
Start date July 2016
Completion date May 2021
View Details
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