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Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI

Traumatic Brain Injury Clinical Trial

Official title:
Cannabidiol for Treating PTSD Symptoms and Neurocognitive Impairment in PTSD and PTSD Comorbid With TBI: A Placebo-controlled RCT With Neural-circuit Centered Precision Medicine Prediction of Response.

Clinical Trial Summary

This will be a randomized placebo controlled study to test the efficacy of cannabidiol (CBD) as a treatment for symptoms of post-traumatic stress disorder (PTSD). Subjects, 120 in total, will be males and females with PTSD, half of which will have comorbid mild traumatic brain injury (TBI). There will be three study arms, each with 40 subjects: 1) Oral CBD 400 mg daily; 2) Oral CBD 800 mg daily, and 3) Placebo daily. Treatment duration will be 8 weeks. The primary outcome will be change in PTSD symptoms as measured by change in the Clinician-Administered PTSD Scale (CAPS-5) total score.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04550377
Study type Interventional
Source NYU Langone Health
Contact Esther Blessing, MD PhD
Phone 646-754-4808
Email Esther.Blessing@nyulangone.org
Status Recruiting
Phase Phase 2
Start date May 26, 2021
Completion date June 2026
View Details
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