Clinical Trials Logo

Traumatic Brain Injury clinical trials

View clinical trials related to Traumatic Brain Injury.

Filter by:

NCT ID: NCT02218216 Terminated - Clinical trials for Traumatic Brain Injury

TBI MR Study 3 Houston Methodist

Start date: September 2014
Phase: N/A
Study type: Interventional

This hypothesis-generating feasibility study to determine potential associations between a broad range of clinical neurological symptoms and Magnetic Resonance Image (MRI), data, and clinical findings involved in mild traumatic brain injury (mTBI). These associations will be examined over the acute and sub-acute period (baseline to 3 months) following injury to provide information useful for optimization of MR pulse sequences for mTBI applications. The intent of this study is to broadly generate a range of potential mTBI biomarkers detectable using investigational MR pulse sequence technologies. Feasibility data attained in this study may be used for engineering program decision-making and in support of future scientific assessment, engineering development, published research databases or registries mTBI data and images, and other purposes determined by the Sponsor. The results of this study are not intended for use in regulatory submissions. Subjects will be examined on commercially available MR scanner using investigational or standard of care MR coils and a series of investigational Application Packs containing a predetermined set of MR pulse sequences optimized by Sponsor

NCT ID: NCT02148783 Terminated - Clinical trials for Traumatic Brain Injury

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

Start date: September 2014
Phase: Phase 2
Study type: Interventional

Deficits in memory, attention, cognitive, and executive functions are the most common disabilities after traumatic brain injury (TBI). Dopamine (DA) neurotransmission is implicated in these neural functions and dopaminergic pathways are recognized to be frequently disrupted after TBI. One of the most widely used DAergic drugs is methylphenidate (Ritalin®). Methylphenidate increases synaptic DA levels by binding to presynaptic dopamine transporters (DAT) and blocking re-uptake. PET with methylphenidate challenge to measure tonic DA release provides valuable insight into the molecular basis of attention-deficit hyperactivity disorder (ADHD) and addiction, as well as practical information regarding likely effectiveness of therapy (1). The objectives of this study are to use PET imaging with [11C]-raclopride, a D2/D3 receptor ligand, before and after administering methylphenidate, to measure endogenous DA release in patients who are experiencing problems with cognition, attention and executive function in the chronic stage after TBI. In addition, we will use TMS to test short intracortical inhibition, a gamma-aminobutyric acid receptor A (GABAA) - mediated phenomenon, which is under partial DA control, as a measure of dopaminergic activity on and off methylphenidate.

NCT ID: NCT02141360 Terminated - Clinical trials for Traumatic Brain Injury

Advanced MRI Applications for Mild Traumatic Brain Injury - UCSF

TBI-2
Start date: July 2014
Phase: N/A
Study type: Interventional

This hypothesis-generating feasibility study is being conducted to determine potential associations between a broad range of clinical neurological symptoms and MR images, data, and clinical findings involved in mild traumatic brain injury (mTBI). These associations will be examined over the acute and sub-acute period (approximately 3 months) following injury to provide information useful for optimization of MR pulse sequences for mTBI applications. The intent of this study is to broadly generate a range of potential mTBI biomarkers detectable using investigational MR pulse sequence technologies. Feasibility data attained in this study may be used for engineering program decision-making and in support of future scientific assessment, engineering development, published research databases or registries mTBI data and images, and other purposes determined by the Sponsor. The results of this study are not intended for use in regulatory submissions. Subjects will be examined on commercially available MR scanners using investigational or standard of care MR coils and a series of investigational Application Packs containing a predetermined set of MR pulse sequences optimized by GEHC.

NCT ID: NCT02070588 Terminated - Clinical trials for Traumatic Brain Injury

Advanced MRI Applications for Mild Traumatic Brain Injury

TBI
Start date: February 2014
Phase: N/A
Study type: Interventional

This feasibility study is being conducted to determine potential associations between a broad range of clinical neurological symptoms and magnetic resonance images (MRI), data, and clinical findings involved in mild traumatic brain injury (mTBI). These associations will be examined over the acute and sub-acute period (approximately 3 months) following injury to provide information useful for optimization of MR pulse sequences for mTBI applications. Correlations exist over the sub-acute period in clinical neurological and MR data (images, image reads, and RAW data), which may indicate temporal evolution patterns. The intent of this study is to broadly generate potential biomarkers of temporal evolution of mTBI detectable in MR images and data ("MR mTBI biomarkers").

NCT ID: NCT02036333 Terminated - Clinical trials for Traumatic Brain Injury

The Role of Cerebral Oximetry in Pediatric Concussion Assessment

Start date: January 2014
Phase: N/A
Study type: Observational

The purpose of this study is to determine whether there is a difference in cerebral oxygenation as measured by near-infrared spectroscopy (NIRS) in children with concussion and healthy controls.

NCT ID: NCT01939769 Terminated - Clinical trials for Traumatic Brain Injury

Effects of Exercise on Memory in Healthy and Brain-Injured Individuals

Start date: August 31, 2013
Phase: Phase 1
Study type: Interventional

Background: - Research has shown that one exercise session may improve a person s ability to recall information they learned before the exercise. Knowing how exercise changes brain activity to improve memory can help researchers understand how memory works and how to improve it in people with memory problems. This study compares two kinds of exercise on a stationary bike for their ability to temporarily improve memory on certain tests. Researchers will look at the effect of exercise on body chemistry by drawing blood and collecting saliva. Objectives: - To understand how a single session of exercise affects memory testing in healthy people and people who have had traumatic brain injury (TBI). Eligibility: - Adults ages 18 through 45 with TBI. - Healthy adult volunteers, ages 18 through 45. Design: - Participants will be screened with medical history and physical exam. This will take about 1 hour. - Participants with TBI will also be screened with a test of their memory. This will take another hour. - Visit 1 will take about 3 hours. Participants will: <TAB>- Have a tube inserted in their arm for drawing blood during the tests. <TAB>- Take memory tests. They will look at pictures, symbols, and words, then answer questions. <TAB>- Give a saliva sample by chewing on a small sponge for 2 minutes. <TAB>- Exercise on a stationary bike. <TAB>- Take the memory tests again. - Visit 2 will take place 1 week later. Participants will take the memory tests only.

NCT ID: NCT01890304 Terminated - Clinical trials for Traumatic Brain Injury

Longitudinal Study of Traumatic Brain Injury (TBI) in (University of Florida) UF Athletes

GATOR TBI
Start date: July 2013
Phase: N/A
Study type: Interventional

To identify the changes in the brain following repeated sports-related concussion in men's football, women's soccer, and women's lacrosse college athletes by reviewing the findings of MRI studies that look at the structure of the brain and the appearance of the white matter at baseline, during the acute phase of a concussive injury, and upon completion of collegiate athletic play and correlate these findings with standard clinical measures.

NCT ID: NCT01814982 Terminated - Clinical trials for Traumatic Brain Injury

An Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics Study of JNJ-17299425 in Participants With Traumatic Brain Injury

Start date: August 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (explores what the body does to the drug) and pharmacodynamics (the study of the action or effects a drug has on the body) of JNJ-17299425 in participants with traumatic brain injury (acute and chronic injuries to the brain, including the cerebral hemispheres, cerebellum, and brain stem).

NCT ID: NCT01730443 Terminated - Clinical trials for Traumatic Brain Injury

Blood Biomarkers of Injury and Outcome in Traumatic Brain Injury

BIO-ProTECT
Start date: July 2011
Phase: N/A
Study type: Observational

Blood samples will be drawn on traumatic brain injury patients who are participating in the ProTECT III study.

NCT ID: NCT01712477 Terminated - Clinical trials for Traumatic Brain Injury

A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function

Start date: November 2011
Phase: Phase 4
Study type: Interventional

This is a prospective randomized controlled pilot study in traumatic brain injury (TBI) patients who are sedated with either propofol or midazolam to compare the cytokine response and neuropsychological outcomes with and without elevated blood alcohol levels. Sedation is part of the standard treatment in patients with a TBI and has been proposed as a neuroprotective intervention in head-injured patients. Sedative regimens, such as midazolam and propofol, are not standardized and it is unclear whether sedation has a significant impact on recovery and outcome. A review of propofol versus midazolam in mechanically ventilated patients shows evidence that both provide effective sedation but there is lack of data to support one sedative over the other. Cytokines are released in response to tissue injury and act to generate a variety of physiologic responses. The cytokine elevation has been correlated with the extent of tissue injury. This study will compare the cytokine distribution patterns at specific posttraumatic time points in patients with a TBI sedated with either propofol or midazolam. Additional analysis will compare the cytokine response in patients whom had elevated blood alcohol levels with those with normal levels. Neuropsychological testing will also be performed to determine the extent of brain injury and recovery.