Traumatic Brain Injury | Patient Clinical Trial
Official title:
Impact of Inspired Oxygen Fraction on Outcome in Patients With Traumatic Brain Injury
Aim of the study is to investigate the impact of two different fractions of inspired oxygen (FiO2) on outcome in patients with severe traumatic brain injury (TBI).
The high oxygen group is treated during mechanical ventilation with either a fraction of
inspired oxygen of 0.7 (high oxygen group) or a fraction of inspired oxygen 0.4 (control
group). The intervention continues until withdrawal of mechanical ventilation, ICU discharge
or until 14 days from ICU randomisation.
Primary outcome is worse than expected outcome in the corresponding treatment arms based on
outcome meas-ured by the probability of bad outcome using the CRASH® risk calculator
(prognostic model for predicting outcome after traumatic brain injury).
Secondary outcome is occurence of lung injury during mechanical ventilation.
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