Traumatic Blunt Chest and/or Blunt Abdominal Injury Clinical Trial
Official title:
Acute Hemodynamic and Ventilatory Responses to Head-down 30° Postural Drainage Position in Critically Traumatic Patients
The purpose of this study is to explore acute hemodynamic and ventilatory responses to head-down 30 degree postural drainage position in patients with blunt chest and/or abdominal injury in the traumatic intensive care unit.
Study Protocol The study protocol consisted of 2 conditions: treatment condition (A) and
sham condition (B). The order of the conditions was randomly assigned to either the
treatment or sham for the first round and vise versa in the second round in a balanced
cross-over design (A-B-B-A) so there were four sets of measurements per patient.
For the treatment condition (A), the study consists of three consecutive periods 1) baseline
period: 10 minutes rest in horizontal supine lying 2) intervention period: 10 minutes rest
in head-down 30 degree supine lying 3) recovery period: return to horizontal supine lying
and rest for 10 minutes . For the Sham condition (B), the study was performed with a similar
procedure except the intervention period consisted of horizontal supine lying.
Hemodynamic and ventilatory parameter were recorded at the start of each period (0 min) and
every 2 minute until end of each period for both conditions. Hemodynamic and ventilatory
dependent variables were heart rate (HR), systolic blood pressure (SBP), diastolic blood
pressure (DBP), mean arterial pressure (MAP), electrocardiography (ECG), central venous
pressure (CVP), respiratory rate (RR), oxygen saturation (SpO2), tidal volume (VT), minute
ventilation (VE), dynamic lung compliance (Cdyn) and end-tidal expiratory pressure of CO2
(PETCO2). Subjects were rested between each condition. Subjects were suctioned via
endotracheal tube to clear airway at 10 minutes before study commencement of either A-B or
B-A.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Open Label