Effect of Hypocalcemia on the Outcome of Elderly Major Trauma Patients With Trauma-induced Coagulopathy

Trauma Clinical Trial

Official title:

Effect of Hypocalcemia on the Outcome of Elderly Major Trauma Patients With Trauma-induced Coagulopathy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05530161
• Other study ID #: 2020-822
• Status: Recruiting
• Start date: January 1, 2015
• Est. completion date: September 1, 2023

Study information

• Verified date: August 2022
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: yongan xu, doctor
• Phone: 13757164833
• Email: xuyongan2000[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Hypocalcaemia is an independent risk factor of TIC in elderly trauma patients. TIC combined with hypocalcemia had worse coagulation function and more serious acidosis.

Description:

This 5-year retrospective, observational, single-center study was conducted at the Second Affiliated Hospital of Zhejiang University Medical School (SAHZU, China). Elderly patients with trauma were registered when they were admitted into intensive care unit affiliated to department of Emergency medicine (EICU) since January 2015 and September 2020.The purpose of this study is to elucidate the effect of hypocalcemia on TIC in elderly trauma patients through a single-center retrospective study, so as to further optimize the diagnosis and treatment strategies for TIC in elderly trauma patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 371
• Est. completion date: September 1, 2023
• Est. primary completion date: September 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years to 100 Years

Eligibility

Inclusion Criteria:

• age=65 years old

• history of trauma

Exclusion Criteria:

• previous anticoagulants or antiplatelet medication;

• Coagulopathy caused by previous underlying diseases;

• Blood products transfused before admission;

• Cardiac arrest on admission;

• Malignant tumor;

• Data incomplete

Related Conditions & MeSH terms

• Blood Coagulation Disorders
• Coagulopathy
• Hemostatic Disorders
• Hypocalcemia
• Trauma
• Wounds and Injuries

Intervention

Other:
• hypocalcemia
hypocalcemia or normocalcemia

Locations

Country	Name	City	State
China	SAHZU	Hanzhou	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Internationalized Normalized Ratio (INR)	coagulation function :Internationalized Normalized Ratio (INR)	24 hour
Primary	Activated Partial Thromboplastin Time (APTT)	coagulation function : Activated Partial Thromboplastin Time (APTT)	24 hour
Primary	Prothrombin Time (PT)	coagulation function : Prothrombin Time (PT)	24 hour
Secondary	Blood products rate	the rate of Blood products use	through study completion, an average of 1 week