Trauma Clinical Trial
Official title:
The Impact of Accidental Hypothermia on Mortality in Trauma Patients Overall and Patients With Traumatic Brain Injury Specifically: A Systematic Review and Meta-Analysis
This is a systematic literature review and meta-analysis investigating the effect of
accidental hypothermia on mortality in trauma patients overall and patients with TBI
specifically.
Literature search will be performed using the Ovid Medline/PubMed database. Studies comparing
the effect of hypothermia vs. normothermia at hospital admission on in-hospital mortality
will be included in meta-analysis.
Accidental hypothermia is a known predictor for worse outcomes in trauma patients, but has
not been comprehensively assessed in meta-analysis so far. The aim of this systematic review
and meta-analysis is to investigate the impact of accidental hypothermia on mortality in
trauma patients overall and patients with traumatic brain injury (TBI) specifically.
Literature search will be conducted using the Ovid Medline/PubMed database. The search
strategy will be based on the PICOS strategy.
Scientific articles reporting (1) accidental hypothermia in trauma patients overall or
patients with TBI specifically, (2) body temperature and time of measurement, and (3) the
impact of accidental hypothermia on outcomes will be included in the qualitative review.
Two meta-analyses will be performed including (1) trauma patients overall and (2) patients
with TBI specifically. Studies reporting in-hospital mortality of hypothermic and
normothermic trauma patients overall or patients with TBI specifically, based on the
temperature measured at Emergency Department admission, will be included in meta-analysis.
Meta-analysis will be performed using a Mantel-Haenszel random-effects model. The estimated
effect size for mortality will be reported as odds ratio (OR) and 95% confidence interval
(CI) for each study as well as for the overall cohort.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04848376 -
Post-Market Clinical Follow-up Study of A-SPINE's Products
|
||
| Terminated |
NCT03781817 -
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
|
Phase 4 | |
| Completed |
NCT04342416 -
Using a Brief Visuospatial Interference Intervention to Reduce Intrusive Memories Among Trauma Exposed Women
|
N/A | |
| Recruiting |
NCT04856449 -
DBT Skills Plus EMDR for BPD and Trauma
|
N/A | |
| Completed |
NCT04356963 -
Adjunct VR Pain Management in Acute Brain Injury
|
N/A | |
| Completed |
NCT05669313 -
The Effects of Hypothermia and Acidosis on Coagulation During Treatment With Rivaroxaban Measured With ROTEM
|
||
| Active, not recruiting |
NCT03622632 -
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
|
||
| Recruiting |
NCT04725721 -
Testing FIRST in Youth Outpatient Psychotherapy
|
N/A | |
| Active, not recruiting |
NCT05530642 -
An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety Personnel
|
N/A | |
| Not yet recruiting |
NCT05649891 -
Checklists Resuscitation Emergency Department
|
N/A | |
| Not yet recruiting |
NCT03696563 -
FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS
|
N/A | |
| Withdrawn |
NCT03249129 -
Identification of Autoantibodies and Autoantigens in the Cerebrospinal Fluid of Patients With Spinal Cord Trauma
|
||
| Completed |
NCT02240732 -
Surgical Tourniquets and Cerebral Emboli
|
N/A | |
| Completed |
NCT02227979 -
Effects of PURPLE Cry Intervention
|
N/A | |
| Withdrawn |
NCT01169025 -
Fentanyl vs. Low-Dose Ketamine for the Relief of Moderate to Severe Pain in Aeromedical Patients
|
N/A | |
| Recruiting |
NCT01812941 -
Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
|
N/A | |
| Completed |
NCT03112304 -
Child STEPS for Youth Mental Health in Maine Sustainability
|
N/A | |
| Completed |
NCT01475344 -
Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC)
|
Phase 1/Phase 2 | |
| Completed |
NCT01201863 -
Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy
|
Phase 4 | |
| Completed |
NCT01210417 -
Trauma Heart to Arm Time
|
N/A |