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Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness

Transient Ischemic Attack Clinical Trial

Official title:
Arteriovenous Plasma Multiomics and Inflammatory Factors in Patients With Disorders of Consciousness

Clinical Trial Summary

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Clinical Trial Description

Background:It is unclear what substances the brain needs to ingest for its activity under pathological conditions Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis. Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06403176
Study type Observational [Patient Registry]
Source First Affiliated Hospital of Zhejiang University
Contact
Status Completed
Phase
Start date May 1, 2022
Completion date April 30, 2024
View Details
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