Cough Clinical Trial
Official title:
Which is the Better Choice for Extubation in Pediatric Patients: Proactive or Passive?
Smooth extubation process can reduce the complications in recovery time. This study aimed to investigate what is the better time to extubation when children is breathing spontaneously and adequately: waiting until children have movements or wakefulness (passive extubation）or removing endotracheal tube directly (proactive tracheal extubation).
This is a randomized, controlled cross-over trial. The hypothesis of this study is that the different extubation protocol can impact recovery quality in children in post-anaesthesia care unit (PACU). Patients aged 3-7 years were randomized into two equal groups: proactive extubation (Group A) and passive extubation. At the end of surgery, sevoflurane was turned off and patients all delivered into PACU for recovery. Patient was positioned on his or her lateral side. The ventilation was switched to positive airway pressure (CPAP) mode once the patients regained spontaneous respiration. After spontaneous breathing turn to regular and sufficient（tidal volume >6-8 ml/kg, respiratory rate >10 times per minutes , end tidal carbon dioxide concentration >7.19 mmHg）, the trachea tube could be removed. In Group A, patients were extubated in a light plane of anesthesia, when they are still asleep or have swallowing reflex. In Group B, tracheal extubation was performed when the patient regained consciousness, facial grimace, spontaneous eye opening, and purposeful arm movement. After extubation, 2 L/min oxygen was administered with Venturi face mask for 10 min in both groups. Patients were transported to the ward until they breathed air with a patent airway. The extubation time, recovery characteristics and respiratory complication were recorded. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00116337 -
Spinal Cord Stimulation to Restore Cough
|
N/A | |
| Not yet recruiting |
NCT04064333 -
Slow-Stream Expiratory Muscle Strength Training for Veterans With Dysphagia Living in Long-term Care
|
N/A | |
| Recruiting |
NCT02482818 -
Efficacy of Pregabalin on Chronic Cough
|
Phase 1/Phase 2 | |
| Terminated |
NCT02269761 -
Chest Ultrasound of ER Patients With Cough or SOB
|
||
| Active, not recruiting |
NCT02065440 -
The Effect of Ebastine/Pseudoephedrine on Subacute Cough
|
N/A | |
| Completed |
NCT01071161 -
The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough
|
Phase 3 | |
| Terminated |
NCT00668317 -
Bronchial Hyper-responsiveness in Reflux Cough
|
Phase 3 | |
| Completed |
NCT00353951 -
An Observational Study of Cough / Lower Respiratory Tract Infection (LRTI) in Primary Care
|
N/A | |
| Completed |
NCT00127686 -
Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep
|
Phase 1 | |
| Completed |
NCT00287339 -
The Utility of Nexium in Chronic Cough and Reflux Disease
|
Phase 4 | |
| Recruiting |
NCT05115097 -
AI Evaluation of COVID-19 Sounds (AI-EChOS)
|
||
| Recruiting |
NCT04457011 -
Efficacy and Safety of Susu Zhike Granules for Treating Acute Cough Due to Common Cold With Cold-cough Syndrome in Children
|
Phase 2 | |
| Recruiting |
NCT05042063 -
Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease
|
||
| Recruiting |
NCT03922373 -
A Study of Benzonatate Soft Capsule in Chinese Healthy Subjects
|
Phase 1 | |
| Completed |
NCT05812209 -
Stellate Ganglion Block to Treat Long COVID 19 Case Series
|
||
| Recruiting |
NCT04767074 -
A Non-pharmacological Cough Control Therapy
|
N/A | |
| Recruiting |
NCT05570539 -
Assessment of the Pharmacokinetics of BLU-5937 Extended Release Prototypes and a BLU-5937 Immediate Release Reference Formulation
|
Phase 1 | |
| Completed |
NCT03999203 -
A Cross-sectional Study to Measure Cough in Severe Asthma
|
N/A | |
| Active, not recruiting |
NCT05479929 -
Work of Breathing Assessment in Triage Scale
|
||
| Recruiting |
NCT02495571 -
Assessment of Voluntary and Reflex Cough in Patients With ALS
|
N/A |