Cough Clinical Trial - Efficacy of Pregabalin on Chronic Cough

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine if Pregabalin, a medication used for the treatment of seizures and chronic pain, can be used to effectively treat people who suffer from non-asthmatic chronic cough (cough lasting over 8 weeks).

Clinical Trial Description

A significant number of patients have an impaired quality of life due to chronic cough that fails to respond to therapeutic efforts.

Research suggests that patients with chronic cough may have an oversensitive cough reflex. Reflexes are involuntary responses to nerve stimulation. Since standard cough medicines may not be helpful for treating the oversensitive cough reflex, treatment with neurologically acting agents has been investigated.

Existing work in treatment of cough of unknown etiology has focused on the use of Gabapentin, a compound that acts neurologically that is used in the treatment of epilepsy and pain. A similar drug, Pregabalin, may be a superior medication for this indication. Pregabalin is rapidly absorbed with peak blood concentrations within 1 hour, has an approximate bioavailability of 90%, and is 3 to 10 times more potent than Gabapentin and has no known pharmacokinetic drug interactions. ;

Study Design

Related Conditions & MeSH terms

Cough

Clinical Trial Details

NCT number	NCT02482818
Study type	Interventional
Source	Ottawa Hospital Research Institute
Contact	Kayvan Amjadi, MD
Phone	613-798-5555
Email	kamjadi@toh.on.ca
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	September 2015
Completion date	December 31, 2021

View Details

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