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Tobacco Use clinical trials

View clinical trials related to Tobacco Use.

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NCT ID: NCT06442384 Not yet recruiting - Tobacco Use Clinical Trials

Remote Trial - Tobacco Product Standard (VLNC)

Start date: November 1, 2024
Phase: N/A
Study type: Interventional

The goal of this pilot project is to explore the feasibility of a real-world marketplace study design examining the effects of a reduced nicotine product standard for cigarettes on smoking in the context of a flavor restriction vs. no restriction on e-cigarettes in smokers switched to very low nicotine content cigarettes.

NCT ID: NCT06438549 Recruiting - Tobacco Use Clinical Trials

Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation

SFHOPE
Start date: May 24, 2024
Phase: N/A
Study type: Interventional

This develops a novel behavioral tobacco cessation program for pregnant smokers in San Bernardino County.

NCT ID: NCT06372899 Not yet recruiting - Tobacco Use Clinical Trials

Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

Start date: July 2024
Phase: N/A
Study type: Interventional

This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instructed to switch (versus smoking cigarettes) over a 6-week period. Relative reductions in biomarkers of exposure will be measured. ECIG- and ONP-associated subjective reward and the reinforcing value of ECIGS and ONPS relative to combustible cigarettes will be assessed as mechanisms.

NCT ID: NCT06356610 Recruiting - Tobacco Use Clinical Trials

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

Start date: February 6, 2024
Phase: N/A
Study type: Interventional

This is a randomized, controlled, six-way crossover clinical study to characterize the nicotine PK (pharmacokinetic) and subjective effects of HTPs (Heated Tobacco Products) comprised of 2 menthol varieties and 2 tobacco flavor varieties (Ploom® HTPs, Japan Tobacco Inc.) in adult menthol and non-menthol combustible cigarette smokers (males and females between the ages of 22 and 65). The study will include participants' UBCC (Usual Brand Combustible Cigarette) and a nicotine gum (Nicorette®) as high and low abuse liability reference products, respectively, to the HTP. Study participation is expected to last up to 34 days, including a 28-day screening period (that includes a 5-day at-home HTP product trial period), and a 6-day in-clinic confinement period (from Check-in [Day -1] through the end-of-study [EOS] visit on Day 6).

NCT ID: NCT06310187 Not yet recruiting - Oxidative Stress Clinical Trials

Little Cigar Oxidants

Start date: July 2024
Phase: N/A
Study type: Interventional

Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 6 exposure groups. These include a high oxidant unflavored little cigar exposure condition, a low oxidant unflavored little cigar exposure condition, a high oxidant flavored exposure condition, a low oxidant flavored exposure little cigar exposure condition, their usual cigarette, and a control condition (unlit little cigar). Following the smoking of each product, exhaled breath condensate samples will be collected at baseline, 30, 60, 90, 120 and 150 minutes. Samples will be analyzed for levels of oxidant markers including hydrogen peroxide, 8-isoprostanes, and C-reactive protein, as well as nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN).

NCT ID: NCT06303115 Not yet recruiting - Smoking Clinical Trials

CSD231005 Nicotine Pouch Biomarkers of Exposure

Start date: July 15, 2024
Phase: N/A
Study type: Interventional

This will be a multi center open label, randomized, controlled, switching parallel-group study designed to assess changes in select biomarkers of exposure (BoE) in generally healthy smokers following a 5 day in-clinic switch to use of nicotine Pouch investigational products (IPs) compared to continued usual brand (UB) cigarette smoking or smoking abstinence.

NCT ID: NCT06295757 Not yet recruiting - Nicotine Dependence Clinical Trials

Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures

Start date: July 1, 2024
Phase: N/A
Study type: Interventional

Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without relighting) cigarettes in the natural environment and will conduct in-clinic measurements of smoking topography and subjective responses for relit and non-relit cigarettes. Information on relighting patterns and smoking topography collected from each participant will be used to compare machine-measured smoke yields of key harmful constituents when their usual cigarettes are smoked with and without relighting. Hypothesis: Relit cigarettes will produce higher levels of toxicants than non-relit cigarettes.

NCT ID: NCT06264154 Not yet recruiting - Smoking Clinical Trials

The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

Start date: July 2024
Phase: N/A
Study type: Interventional

This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e-cigarettes relative to combustible cigarettes will be assessed as mechanisms.

NCT ID: NCT06234722 Not yet recruiting - Tobacco Use Clinical Trials

Modeling Tobacco Regulatory Impacts in Appalachia Using the Experimental Tobacco Marketplace

Start date: June 1, 2024
Phase: N/A
Study type: Interventional

The goal of this project is to look at the effect of proposed tobacco product regulations in Appalachian Kentucky. Appalachian Kentucky is a diverse and underserved rural area that would benefit from more tobacco regulation research. Researchers will study the effects of three proposed tobacco product regulations among users of tobacco products in Appalachian KY. Researchers will also study how degree of rurality effects how those regulations impact behavior. Participants will be asked to complete online surveys and tests, online shopping sessions in a simulated Experimental Tobacco Marketplace, and track their tobacco product use throughout the 9-week experiment.

NCT ID: NCT06179290 Recruiting - Tobacco Use Clinical Trials

Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products

Start date: October 2, 2023
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smokers who completely switch to Ploom heated tobacco products (HTPs) compared to those who continue to smoke usual brand combustible cigarettes (UBCC).