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Tissue Adhesions clinical trials

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NCT ID: NCT06423066 Not yet recruiting - Lung Cancer Clinical Trials

Developing a Machine Learning Model to Predict Pleural Adhesion Preoperatively Using Pleural Ultrasound

Start date: June 1, 2024
Phase:
Study type: Observational

This study aims to investigate the accuracy of using pleural ultrasound (USP) to identify pleural adhesions in patients who plan to receive video-assisted thoracoscopic surgery. It employs three-dimensional convolutional neural network (3D-CNN) technology to process USP-related images and video data for machine learning, and to establish a diagnostic model for identifying pleural adhesions using 3D-CNN-USP. The study will determine the sensitivity, specificity, positive predictive value, and negative predictive value of 3D-CNN-USP in identifying pleural adhesions. Additionally, it will explore the feasibility and effectiveness of using 3D-CNN-USP for preoperative identification of pleural adhesions in VATS, thereby supporting the implementation of day surgery in thoracic surgery and ultimately serving clinical practice.

NCT ID: NCT06392165 Not yet recruiting - Clinical trials for Adhesion Properties of Wound Care Devices

Evaluation of Adhesion Properties in Wound Care Devices

Start date: April 24, 2024
Phase: N/A
Study type: Interventional

Molnlycke manufactures and markets self-adhesive wound care devices intended to protect various types of wounds during treatment. This study aims to measure and evaluate the adhesion properties of self-adhesive wound care devices. To measure the adhesion properties test strips will be applied to the participant's skin for a predetermined time and will be removed while measuring the adhesion properties afterwards. This method has been chosen since there is no in vitro method available that can simulate adhesion to human skin

NCT ID: NCT06365632 Not yet recruiting - Abdominal Adhesions Clinical Trials

Clinical Study of the Effectiveness, Tolerability and Safety of the Drug "Anti-spike, Gel, 100 g in Bottles in Package No. 1" Produced by the Republican Unitary Enterprise "Unitekhprom BSU", With a Single Intraperitoneal Use After Surgery in Adult Patients With Acute Phlegmonous Appendicitis

OLTOSPAN-02
Start date: July 2024
Phase: Phase 2
Study type: Interventional

The purpose of the clinical trials is the evaluation of the effectiveness and safety of a single intraperitoneal use of the drug "Antispike, gel, 100 g in a bottle" produced by Unitary Enterprise Unitehprom BSU, Belarus in patients after surgical control of acute phlegmonous appendicitis to prevent abdominal adhesions.

NCT ID: NCT06164522 Not yet recruiting - Abdominal Adhesion Clinical Trials

Prediction of Intraoperative Adhesions Before CS

Start date: January 1, 2024
Phase:
Study type: Observational

To predict the presence of intra-abdominal adhesions among women undergoing repeated cesarean section using several parameters.

NCT ID: NCT05923164 Not yet recruiting - Breast Cancer Clinical Trials

Reliability And Validity Study Of "The Evaluation Tool For Myofascial Adhesions In Patients After Breast Cancer" In Turkish Language

MAP-BC
Start date: August 30, 2023
Phase:
Study type: Observational

The aim of this observational study is to translate the MAP-BC Evaluation Tool into Turkish by adapting it to Turkish society and to conduct a validity and reliability study in women who have received breast cancer treatment. The main questions it aims to answer are: - Are the same researcher's MAP-BC Evaluation Tool results similar at intervals to detect myofascial adhesions in breast cancer patients in Turkish population? - Are the different researchers' MAP-BC Evaluation Tool results similar to detect myofascial adhesions in breast cancer patients in Turkish population? - After comparing the results of Turkish version of both The Patient and Observer Scar Assessment Scale Observer Subscale and MAP-BC Evaluation Tool, is there a sufficient correlation between them?

NCT ID: NCT05635071 Not yet recruiting - Uterine Adhesions Clinical Trials

Prospective Clinical Study of Nintedanib to Inhibit Endometrial Fibrosis to Prevent Recurrence of Uterine Adhesions

Start date: December 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

In moderate to severe cavity adhesions, the endometrial basal layer is more severely damaged and the regenerative capacity of the endometrium and glands is low. Even though hysteroscopic electrosurgery can roughly restore the cavity morphology, the postoperative recurrence rate is as high as 40%. Abnormal uterine cavity morphology and poor endometrial repair often lead to repeated cancellation of embryo transfer cycles in assisted reproduction treatment, and reduced clinical pregnancy rate, causing mental stress and financial burden to patients, which is one of the current problems in clinically assisted reproduction treatment. Nintedanib is a triple vascular kinase inhibitor that acts primarily on platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) and has been approved by the FDA for the clinical treatment of idiopathic pulmonary fibrosis and systemic sclerosis. The investigator's preliminary animal study found that endometrial fibrosis was significantly reduced in mice with gastric feeding of nintedanib in uterine adhesion molds. This study aimed to clarify further the role of nintedanib in inhibiting endometrial fibrosis and its clinical application value.

NCT ID: NCT05415059 Not yet recruiting - Adhesion Clinical Trials

LEAFix Adhesion in Healthy Volunteers

Start date: August 10, 2022
Phase: N/A
Study type: Interventional

This study compares the adhesiveness of the 3M material to be used in the final design.

NCT ID: NCT05376787 Not yet recruiting - Clinical trials for Adhesion of the Neutral Electrode 21pad

Medline NE Pad Adhesion Testing

Start date: May 16, 2022
Phase:
Study type: Observational

The purpose of this research study is to determine the neutral electrode 21pad adhesion to the skin in accordance with international standard IEC 60601-2-2 section 201.15.101.7. A neutral electrode is placed on the body of patients undergoing surgery that involves the use of electric current, to protect them from the harmful effects of the electricity.

NCT ID: NCT04641923 Not yet recruiting - Liver Neoplasms Clinical Trials

The Efficacy of a Topical Anti-adhesive Film for Decreasing Perihepatic Adhesions in Repeat Hepatic Surgery

Start date: November 2022
Phase: N/A
Study type: Interventional

There has been an increase in the need for repeat hepatic surgery, especially for patients with colorectal liver metastasis and hepatocellular carcinoma. Adhesions at the time of repeat surgery can lead to increased operative times, higher blood loss and even increased perioperative morbidity. Not much data exists regarding use of anti-adhesion barriers at the time of index hepatectomy and their effect on adhesions at repeat hepatectomy. This randomized controlled trial aims to evaluate the effectiveness of the use of a hyaluronan and cellulose based antiadhesive topical film at index hepatectomy in reducing perihepatic adhesions at the time of repeat hepatic surgery.

NCT ID: NCT04482140 Not yet recruiting - Clinical trials for Tissue Adhesions, Surgery-Induced

Post Approval Study to Evaluate the Safety and Performance of GENTA-FOIL Resorb® in Hand Surgery

Start date: April 2024
Phase:
Study type: Observational

Single arm study to evaluate the safety and performance of Genta-Foil resorb® for the prevention of tissue adhesions