Clinical Trials Logo

Tissue Adhesions clinical trials

View clinical trials related to Tissue Adhesions.

Filter by:

NCT ID: NCT03446755 Completed - Clinical trials for Adhesion; Uterus, Internal

Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR)

Start date: January 17, 2018
Phase: N/A
Study type: Interventional

Patients suffering of subfertility as a consequence of intrauterine adhesions could be treated with hysteroscopic adhesiolysis. Adhesion recurrence may occur postoperative. An intrauterine balloon, inserted after hysteroscopic adhesiolysis, may prevent adhesion reformation. A Foley catheter can serve for this purpose, but its not ideal. COOK medical® developed a hearth shaped intrauterine balloon to reduce bleeding after intrauterine surgery. We aimed to perform a pilot study of 10 procedures with insertion of a hearth shaped intrauterine balloon as antiadhesion method subsequent to a hysteroscopic adhesiolysis, to study its feasibility in terms of surgeon's and patient's experience.

NCT ID: NCT03381807 Recruiting - Clinical trials for Intrauterine Adhesion

Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion

Start date: September 16, 2020
Phase: Early Phase 1
Study type: Interventional

This project will investigate the safety and effectiveness of human amniotic epithelial stem cells for treatment of severe refractory Asherman's syndrome.

NCT ID: NCT03354533 Completed - Clinical trials for Leukocyte Adhesion Deficiency, Type II

Study of ORL-1F (L-fucose) in Patients With Leukocyte Adhesion Deficiency Type II

Start date: January 1, 2012
Phase: Phase 1/Phase 2
Study type: Interventional

Study of ORL-1F in Patients With Leukocyte Adhesion Deficiency Type II

NCT ID: NCT03353909 Completed - Clinical trials for Intrauterine Adhesion

The Efficacy of A New Crosslinked Hyaluronan Gel in Prevention of Intrauterine Adhesion

Start date: July 1, 2016
Phase: N/A
Study type: Interventional

Using American Fertility Society classification of intrauterine adhesions, the efficacy of a new crosslinked hyaluronan gel in reducing intrauterine adhesion formation after dilatation and curettage for delayed miscarriage in women without previous dilatation and curettage was examined.

NCT ID: NCT03351205 Recruiting - Clinical trials for Intrauterine Adhesion

The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis

Start date: November 21, 2017
Phase: N/A
Study type: Interventional

Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility. The gold standard for the treatment of intrauterine adhesions is hysteroscopic intrauterine adhesions. The recurrence of intrauterine adhesions is a major challenge in clinical practice. Intrauterine balloon has been used for the prevention of intrauterine adhesions. It has been reported that dried biological amnion graft was used to prevent adhesion after the operation of intrauterine adhesions. Estrogen is also used for postoperative prevention of intrauterine adhesions. Intrauterine balloon can reduce the recurrence of adhesions after operation. Disposable balloon uterine stent,which is an innovative intrauterine balloon,is specially designed to fit into the cavity of the uterus. Does Disposable balloon uterine stent and amniotic products combine estrogen therapy improve clinical outcomes? Therefore, this study was conducted.

NCT ID: NCT03346317 Recruiting - Clinical trials for Intrauterine Adhesion

Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis

Start date: November 16, 2017
Phase: N/A
Study type: Interventional

Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility. The gold standard for the treatment of intrauterine adhesions is hysteroscopic intrauterine adhesions. The recurrence of intrauterine adhesions is a major challenge in clinical practice. It has been reported that dried biological aminion graft was used to prevent adhesion after the operation of intrauterine adhesions. Estrogen is also used for postoperative prevention of intrauterine adhesions. Intrauterine balloon can reduce the recurrence of adhesions after operation. Does the combination of balloon with amniotic products or estrogen can improve clinical outcomes? Therefore, this study was conducted.

NCT ID: NCT03330873 Recruiting - Clinical trials for Intrauterine Adhesion

The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome

Start date: October 23, 2017
Phase: N/A
Study type: Interventional

Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility. The gold standard for the treatment of intrauterine adhesions is hysteroscopic intrauterine adhesions. The recurrence of intrauterine adhesions is a major challenge in clinical practice. The isolation of barriers in the uterine cavity may be a measure to reduce postoperative re adhesion, but the effect of different devices is different. Therefore, this study was conducted.

NCT ID: NCT03329898 Recruiting - Clinical trials for Intrauterine Adhesion

Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion

Start date: October 31, 2017
Phase: N/A
Study type: Interventional

Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility. The gold standard for the treatment of intrauterine adhesions is hysteroscopic intrauterine adhesions. The recurrence of intrauterine adhesions is a major challenge in clinical practice. It has been reported that dried biological aminion graft was used to prevent adhesion after the operation of intrauterine adhesions. Intrauterine balloon can reduce the recurrence of adhesions after operation. Does the combination of balloon and amniotic products can improve clinical outcomes? Therefore, this study was conducted.

NCT ID: NCT03293186 Completed - Thyroidectomy Clinical Trials

Anti-adhesive Effect and Safety of "Thermo-sensitive Adhesion Barrier (MEDICLORE)"

Start date: July 1, 2017
Phase: Phase 4
Study type: Interventional

One of most important complication of thyroid surgery is adhesion. There are many anti-adhesive materials, but none of them showed significant outcomes. The investigators planned double blind prospective study of "Thermo-sensitive Adhesion Barrier (MEDICLORE)" to reveal anti-adhesive effect of MEDICLORE. The investigators will recruit total 90 patients (control group 45, experimental group 45) and compare postoperative outcomes about adhesion.

NCT ID: NCT03231410 Recruiting - Clinical trials for End Stage Renal Disease

Role of Monocytes Adhesion and Vascular Lesions in Vascular Access Success or Failure in Uremic Patients

ROMAVAS
Start date: January 2017
Phase:
Study type: Observational

This study is designed to identify novel predictors of vascular access success or failure in chronic kidney disease patients. Despite efforts to improve placement of arteriovenous fistula (AVF) the primary failure rates are reported as high as 20-50%, but standard tools like ultrasound cannot inform the clinician sufficiently to accurately predict success or failure. The aim of this study is to perform enhanced assessments of arterial health preoperatively and correlate these measurements with vascular lesions (microscopic tissue changes and monocyte infiltration) and early AVF outcome. Activation of monocytes in uremia condition is responsible for endothelium dysfunction, intimal hyperplasia and atherosclerosis. The investigators expect that stiff arteries caused by monocyte dysfunction refer to the poor distensability and probably longer maturation time.