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Tinnitus clinical trials

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NCT ID: NCT02772536 Completed - Tinnitus Clinical Trials

A Clinical Trial Investigating Effect of Tinted Light on Perception of Tinnitus

Start date: March 10, 2015
Phase: N/A
Study type: Interventional

Background An earlier pilot study provided evidence that about 40% of tinnitus sufferers reported that viewing particular tints of light appeared to result in some improvement of their tinnitus. This ameliorative effect appeared to be primarily acute and only reported to occur whilst viewing the tint. Individual patients would choose differing tints with some identifying more than one tint that affected their tinnitus. Aim of the Study In this current basic science study, the aim is to provide preliminary data to return estimates of the efficacy of using tinted light to ameliorate tinnitus. After identification of responders during screening, responders are invited to attend three further trial sessions, where their tinnitus is assessed in response to three luminance conditions: Low Ambient Light; Tint of Light affecting Tinnitus; White Light. The response to low ambient light serves as a control to compare the effect of tinted light against and the response to white light serves as an 'active' stimulus comparator. These results will then establish whether tinted light provides patients with a useful improvement in their tinnitus compared with measures of their baseline tinnitus obtained in the dark and against a standardised white light stimulus. They will also inform further development of the technique as a potential treatment for tinnitus in responsive patients. Over the three sessions, the averaged responses given by the patient under each stimulus condition will be analysed to provide a measure of efficacy.

NCT ID: NCT02750969 Recruiting - Tinnitus Clinical Trials

Lidoderm Patch (Lidocaine 5%) for Tinnitus Treatment

Start date: April 2016
Phase: Phase 4
Study type: Interventional

The investigators like to learn whether Lidoderm patch (lidocaine 5%) helps tinnitus patients. so far it is known that lidocaine I.V do helps tinnitus but until now it is not clear if other means of drug delivery (e.g lidocaine patch) help tinnitus. The investigators are going to compare 1 day of treatment with lidoderm patch cream Versus (VS.) tegaderm patch (containing no drug) in treating tinnitus patients.

NCT ID: NCT02737670 Completed - Clinical trials for Tinnitus, Subjective

Sulodexide Efficacy in Chronic Idiopathic Subjective Tinnitus

SECIST
Start date: August 2014
Phase: Phase 2
Study type: Interventional

The objective of this prospective randomized and double blind controlled study is to evaluate the efficacy and safety of Sulodexide (25 mg) in the treatment of chronic idiopathic subjective tinnitus.

NCT ID: NCT02734576 Terminated - Tinnitus Clinical Trials

Venous Sinus Stenting To Treat Intractable Pulsatile Tinnitus Caused By Venous Sinus Stenosis

Start date: January 24, 2017
Phase: N/A
Study type: Interventional

There have been few published studies that examine the efficacy and safety of endovascular treatments on patients with pulsatile tinnitus with venous stenosis. Despite the limited experience with venous sinus stenting to treat pulsatile tinnitus, preliminary results show that venous sinus stenting could represent a viable alternative for refractory pulsatile tinnitus patients with venous sinus stenosis. The purpose of this study is to evaluate the safety and efficacy of this procedure in a controlled fashion, using strict inclusion and exclusion criteria, and long-term clinical and imaging follow-up. The investigators hope to provide robust data regarding the safety and efficacy of venous sinus stenting for patients with pulsatile tinnitus.

NCT ID: NCT02717065 Withdrawn - Tinnitus Clinical Trials

Variability of Tinnitus Characterization Tools and Investigation of Audiovisual Integration in Tinnitus Perception

Start date: June 2017
Phase: N/A
Study type: Interventional

Characterizing the nature and severity of tinnitus in individuals presents a particular challenge. The nature of the sound (loudness and pitch) is not necessarily indicative of the effect on quality of life. Different methods are used to measure each parameter. Loudness is measured using a technique called "minimum masking," in which the subject is presented with a broadband white noise and asked to adjust the loudness level until they can no longer hear their tinnitus. Severity of tinnitus is commonly characterized using two questionnaires: the Tinnitus Handicap Inventory (THI) and the Tinnitus Functional Index (TFI). These questionnaires assess the perceived severity of the tinnitus and the effect on everyday activities and quality of life. A visual analog scale (a scale from 0-10) is used as a general subjective measurement of tinnitus severity. In the first part of this study, we will measure each of these parameters over a series of sessions to establish a baseline variability for each individual. The second part will look at the influence of context-specific visual information on auditory perception. This involves watching silent videos of a person speaking, with and without an additional tone designed to match the subject's tinnitus. The effect of this audiovisual feedback on the subject's perception of tinnitus will be assessed using a subjective rating scale and the minimum masking task.

NCT ID: NCT02684890 Recruiting - Tinnitus Clinical Trials

Detection of Emotions in a Spoken Language Among Tinnitus Patients

EMSLT
Start date: March 2016
Phase: N/A
Study type: Observational

Tinnitus may affect the ability of patients to detect emotions in spoken language. This study will compare this ability between tinnitus patients and non-tinnitus patients.

NCT ID: NCT02669069 Completed - Tinnitus Clinical Trials

Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A)

Start date: June 27, 2016
Phase: N/A
Study type: Interventional

This is a three arm, patient subtyping and parameter optimisation study for a neuromodulation treatment for tinnitus.

NCT ID: NCT02665975 Completed - Tinnitus Clinical Trials

Internet-based Versus Face-to-face Clinical Care for Tinnitus

Start date: August 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the effectiveness of a CBT-based internet intervention with face to face standard clinical care for adults with tinnitus in the United Kingdom.

NCT ID: NCT02653547 Completed - Chronic Tinnitus Clinical Trials

Influence of Treatment Duration and Stimulation Frequency on rTMS in Chronic Tinnitus

Start date: January 2016
Phase: N/A
Study type: Interventional

Patients receive two weeks of treatment (prefrontal high-frequency and bilateral low-frequency rTMS vs. prefrontal high-frequency and bilateral high-frequency rTMS). After two weeks of treatment they can decide if they want to quit the treatment or if they want to proceed with the treatment for another two weeks.

NCT ID: NCT02648542 Completed - Tinnitus Clinical Trials

The Effects of Compensatory Auditory Stimulation and Transcranial Direct Current Stimulation on Tinnitus Perception

Start date: March 2013
Phase: N/A
Study type: Interventional

This study evaluates the ability of compensatory auditory stimulation (CAS) and transcranial direct current stimulation (tDCS) to help alleviate tinnitus. Subjects will receive CAS, tDCS, and the combination of the two to assess the effectiveness of the treatment.