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Thyroid clinical trials

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NCT ID: NCT04208503 Recruiting - Thyroid Clinical Trials

Ultrasound and Functional Thyroid Evaluation

Start date: December 19, 2019
Phase:
Study type: Observational [Patient Registry]

Thyroid disorders are most commonly concomitant with prematurity and still remains a controversial topic. The incidence of a temporary form of hypothyroidism among preterm neonates is higher than in the general population. Transient prematurity hypothyroxinemia is defined as a temporary reduction in FT4 values without increase in TSH values. Currently, there is no consensus about normal thyrotropine (TSH) and free thyroxine (FT4) values in preterm infants. The aim of this study is to determine the volume of the thyroid gland in preterm infants born between 24 and 32 weeks of gestation inborn or admitted to the unit within 14 days from birth and compare it with the results of TSH and FT4 blood concentration. Besides, the objective of the study is to determine values of thyroid hormones in premature infants born before 33 wk gestation to help neonatologist to interpreter the thyroid hormone results

NCT ID: NCT04180007 Recruiting - Metastasis Clinical Trials

Study of Neoadjuvant Regimen for Radioactive Iodine Treatment of Metastatic and Advanced Differentiated Thyroid Cancers

APT-01
Start date: April 10, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine Safety and Efficacy of Radioactive Iodine (RAI) Treatment of Metastatic and Advanced Differentiated Thyroid Cancers by Pretreatment With Apatinib for the Neoadjuvant Regimen

NCT ID: NCT04160637 Recruiting - Clinical trials for Postoperative Complications

Is There Benefit From Early Postoperative PTH Monitoring?

Start date: September 1, 2019
Phase:
Study type: Observational

This study is designed as a prospective non-randomized longitudinal single-center cohort study. It will enroll around 120 patients undergoing total thyroidectomy with data being collected from September 2019 up to December 2019. The hypothesis is that a significant association and cut-off point in PTH levels may be established with regard to postoperativne hypocalcaemia. Primary outcome measures are presence of hypocalcemia on the first and fifth postoperative day. Secondary outcome measures are the need for calcium supplement therapy during the first five postoperative days and amount of medication given. Associations between variables will be assessed using Spearman's rho rank correlation coefficient, the Kruskal-Wallis test for independent samples and a logistic regression model to test statistically significant correlations between PTH and serum calcium values as a primary end point.

NCT ID: NCT04115514 Recruiting - ARDS, Human Clinical Trials

Treatment of ARDS With Instilled T3

ARDS+T3
Start date: October 21, 2019
Phase: Phase 2
Study type: Interventional

It is hypothesized that instillation of Liothyronine Sodium (T3) into the airspace will be safe, well tolerated, and will increase alveolar fluid clearance and decrease inflammation in patients with ARDS, reflected in improved oxygenation index (OI) and oxygenation saturation index (OSI).

NCT ID: NCT04014660 Recruiting - Type 1 Diabetes Clinical Trials

Prevention av Autoimmunitet Med Laktobaciller

PAL
Start date: October 1, 2019
Phase: N/A
Study type: Interventional

The incidence of autoimmune diseases (celiac disease, type 1 diabetes, thyroid disease) have increased over the past 30 years. Although most autoimmune diseases have a strong link to different risk genes, the rapid increase is thought to be due to changes in environmental factors. There is currently no cure for autoimmune diseases, but the treatment is lifelong and either involves suppressing the inflammation and / or substituting the organs that are affected to maintain vital functions. Being able to predict who is affected and identifying factors that trigger autoimmunity is necessary for developing new treatment methods that prevent the occurrence of autoimmune diseases. The bacterial flora's composition in the gut can affect both the intestinal barrier properties and the immune system's response to various dietary components. An adverse composition of the intestinal flora can activate parts of the immune system that are involved in chronic inflammation in celiac disease and inflammatory bowel disease. Probiotics are defined as living microorganisms which, when ingested in sufficient amounts, produce a health effect (FAO / WHO). The aim of the study is to investigate whether a daily oral intake of a mixture of L.paracasei and L.plantarum can affect the autoimmune process in children who are screened positive for any of the autoantibodies associated with development of celiac disease, type 1 diabetes and / or thyroid disease. Our hypothesis is that lactobacilli can directly regulate the autoimmune process in the small intestinal mucosa by stimulating regulatory T-cells, but also by affecting the permeability of the small intestinal mucosa by of antigen that stimulates specific T-cells.

NCT ID: NCT03933358 Recruiting - STEMI Clinical Trials

Effect of Thyroid Hormone on Post-Myocardial Infarction Remodeling and Prognosis in STEMI Patients

ThyREST
Start date: May 1, 2019
Phase:
Study type: Observational

This study aims to determine whether thyroid hormone levels are predictive of cardiac remodeling following myocardial infarction and the prognosis in patients with STEMI receiving primary percutaneous coronary intervention.

NCT ID: NCT03754621 Recruiting - Hypothyroidism Clinical Trials

Upper Limit for TSH of First and Second Trimester Pregnancy in Turkey

Start date: October 15, 2018
Phase:
Study type: Observational

Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this may lead to overdiagnosis or even overtreatment. The new guidelines of the American Thyroid Association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accordingly. Any hospital or physician that is still using the 2.5 or 3.0 mU/l cut-off for TSH during pregnancy should evaluate their own lab-specific cut-offs. The investigator's objective is to establish a rational reference range of serum TSH for diagnosis of subclinical hypothyroidism in the first and second trimester of pregnant women in west Black Sea region in Turkey.

NCT ID: NCT03309384 Recruiting - Thyroid Clinical Trials

Intraoperative Monitoring to Predict Postoperative Complications After Thyroidectomy

PARACAL
Start date: March 20, 2016
Phase:
Study type: Observational [Patient Registry]

The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.

NCT ID: NCT03149354 Recruiting - HIV Infections Clinical Trials

Prevalence of Thyroid Function Abnormalities in HIV-infected Patients

THYVI
Start date: December 19, 2012
Phase: N/A
Study type: Interventional

Review the evolution of thyroid function in HIV-infected patients, with sufficient follow-up.

NCT ID: NCT03093285 Recruiting - Thyroid Clinical Trials

Dysthyroidism and Female Sexual Function

Start date: January 2017
Phase:
Study type: Observational

The aim of the study is to evaluate the incidence of sexual dysfunction in presence of dysthyroidism and the impact of restoring euthyroidism on female sexual function