Thoracic Surgery Clinical Trial
Official title:
The Effect of Different Anesthesia Techniques on Cerebral Oxygenation in Thoracic Surgery
NCT number | NCT04760262 |
Other study ID # | 2013/21 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | March 1, 2017 |
Est. completion date | January 20, 2020 |
Verified date | February 2021 |
Source | Karadeniz Technical University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
One-lung ventilation (OLV) may cause negative changes in the oxygenation of cerebral tissue which results in postoperative cognitive dysfunction. The aim of this prospective study was to compare the potential effects of TIVA and inhalation general anesthesia techniques on cerebral tissue oxygenation and postoperative cognitive functions in patients receiving one-lung ventilation in thoracic surgery
Status | Completed |
Enrollment | 30 |
Est. completion date | January 20, 2020 |
Est. primary completion date | June 15, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Patients in American Society of Anesthesiology (ASA) classification I and II - Patients who would undergo thoracic surgery with one-lung ventilation (OLV) - thoracic surgeries with one-lung ventilation (OLV) that will take at least 45 minutes Exclusion Criteria: - Patients in ASA classification III and higher - Emergency surgery - Patients with known allergy to drugs used in the study - Patients in New York Heart Association classification III-IV - severe metabolic, renal, hepatic, central nervous system diseases, alcohol or drug addiction - multiple trauma, coagulapathy, cerebral disease, dementia, hearing impairment and imperception - severe obesity (a body mass index (BMI) of = 35) - patients with a peripheral oxygen saturation below 90 during one lung ventilation |
Country | Name | City | State |
---|---|---|---|
Turkey | Karadeniz Technical University | Trabzon |
Lead Sponsor | Collaborator |
---|---|
Karadeniz Technical University |
Turkey,
Aguirre JA, Märzendorfer O, Brada M, Saporito A, Borgeat A, Bühler P. Cerebral oxygenation in the beach chair position for shoulder surgery in regional anesthesia: impact on cerebral blood flow and neurobehavioral outcome. J Clin Anesth. 2016 Dec;35:456-464. doi: 10.1016/j.jclinane.2016.08.035. Epub 2016 Oct 18. — View Citation
Hood R, Budd A, Sorond FA, Hogue CW. Peri-operative neurological complications. Anaesthesia. 2018 Jan;73 Suppl 1:67-75. doi: 10.1111/anae.14142. Review. — View Citation
Kazan R, Bracco D, Hemmerling TM. Reduced cerebral oxygen saturation measured by absolute cerebral oximetry during thoracic surgery correlates with postoperative complications. Br J Anaesth. 2009 Dec;103(6):811-6. doi: 10.1093/bja/aep309. — View Citation
Mahal I, Davie SN, Grocott HP. Cerebral oximetry and thoracic surgery. Curr Opin Anaesthesiol. 2014 Feb;27(1):21-7. doi: 10.1097/ACO.0000000000000027. Review. — View Citation
Nakayama M, Murray PA. Ketamine preserves and propofol potentiates hypoxic pulmonary vasoconstriction compared with the conscious state in chronically instrumented dogs. Anesthesiology. 1999 Sep;91(3):760-71. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Near Infrared Spectroscopy | Cerebral oxygen saturation as measured by Near Infrared Spectroscopy | Duration of surgery | |
Primary | Mini mental state examination (MMSE) | Mini mental state examination (MMSE) to evaluate patients' cognitive functions | 3 to 24 hours postoperative period | |
Secondary | mean arterial pressure | The effect of anesthetics on mean arterial pressure | Duration of surgery | |
Secondary | heart rate | The effect of anesthetics on heart rate | Duration of surgery | |
Secondary | bispectral index | The effects of sevoflurane and desflurane on bispectral index | Duration of surgery |
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