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Perioperative Troponin I and NT Pro-BNP in Lung Resection

Thoracic Cancer Clinical Trial

Official title:
Incidence and Clinical Relevance of Perioperative Elevation of Troponin I and N- Terminal Pro-Brain Natriuretic Peptide in Patients Undergoing Lung Resection

Clinical Trial Summary

After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery. Integrating both cardiac biomarkers may improve the predictive value for cardiovascular complications after lung resection.

Clinical Trial Description

Objectives: To evaluate the incidence and magnitude of perioperative N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (Tn I) elevation in patients undergoing pulmonary resection and its predictive value for cardiovascular complications. Methodology: Prospective, multicenter, observational cohort study in patients >45 years undergoing elective thoracic surgery for lung resection. Cardiac biomarkers Tn I and NT-proBNP will be measured preoperatively and at postoperative days 1 and 2. Risk score for major cardiovascular postoperative complications will be calculated depending of both biomarkers perioperative changes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04749212
Study type Observational
Source Hospital Universitari Vall d'Hebron Research Institute
Contact Miriam De Nadal Clanchet, MD, PhD
Phone 934 89 30 00
Email miriam.denadal@vallhebron.cat
Status Recruiting
Phase
Start date May 19, 2021
Completion date December 31, 2023
View Details
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