Obesity Clinical Trial
To examine the biobehavioral determinants of obesity in Black as compared with white women.
BACKGROUND:
Behavioral medicine surveys consistently find that obesity is a treatment-resistant disease
that continues to be a significant health problem and that the incidence of obesity is much
higher in Blacks relative to whites in general, and even higher in Black women relative to
white women. In fact, an NIH Program Announcement (PA-91-99), stated that "Obesity in adults
has not declined in the past three decades" and "Obesity is particularly prevalent in
minority populations, especially among minority women." Obesity is an independent risk
factor for cardiovascular disease, stroke, and hypertension. Obesity is a complex phenomenon
involving behavioral, lifestyle, and complex biobehavioral mechanisms. In 1995, there were
no prospective studies that simultaneously evaluated a systematic set of psychosocial
variables with energy balance (dietary intake, physical activity, resting metabolic rate)
determinants that may account for the increased risk for obesity in African-American versus
Euro-American women.
DESIGN NARRATIVE:
After subjects were recruited, psychosocial and energy balance (dietary intake, physical
activity, metabolic rate) baseline measures were related to levels of body fat as measured
by DEXA (dual electron X-ray absorptiometry). The role of these variables were evaluated
prospectively to adiposity changes in both white and Black women over a 24-month period.
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