Systemic Sclerosis Clinical Trial
Official title:
Ultrasonography Features of the Salivary Glands in Patient With Systemic Sclerosis: Comparison With Gougerot-Sjogren Syndrome and Sicca Asthenia Polyalgia Syndrome
Systemic sclerosis is an autoimmune connective tissue disease with undefined etiology and
characterized by progressive fibrosis of the skin and major organs. Dry eyes and / or buccal
syndrome is commonly reported in patients with systemic sclerosis. Goujerot-Sjogren syndrome
is a chronic autoimmune disorder that is characterized by dryness of the eyes (xerophthalmia)
and / or mouth (xerostomia). It may be primary or secondary to another connective tissue
disease (such as lupus, rheumatoid arthritis or other). Several criteria have been validated
to classify the SS but require a labial salivary gland biopsy, invasive act which
complications can sometimes be reported (hematoma, lip sensory defect).
Several scores based on the evaluation of the ultrasound homogeneity of the salivary glands
were developed but no studies have evaluated ultrasound abnormalities of salivary glands in
patients with systemic sclerosis.
Descriptive explorative study of three population showing sicca symptoms (Systemic sclerosis,
Gougerot-Sjogren syndrome, Sicca-Asthenia-Polyalgia syndrome).
Patient will be enrolled in the rheumatology department of University hospital of
Clermont-Ferrand (France).
Salivary glands ultrasonography will be performed on all patients enrolled by the same expert
and blinded to the diagnosis of the patient. Echostructure of the two salivary glands will be
graded 0 to 4 and the size calculated.
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