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Study to Evaluate the Safety, Tolerability, and Activity of CM-101 in Patients With Systemic Sclerosis — ABATE  

Systemic Sclerosis Clinical Trial

Official title:
A Phase 2, Multicenter, Randomized, Double-Blind, Proof of Biology Study to Evaluate the Safety, Tolerability, and Activity of CM-101 in Patients With Systemic Sclerosis

Clinical Trial Summary

This study is designed to assess the safety and tolerability of the anti-human CCL24 monoclonal antibody CM-101 in adult patients with systemic sclerosis (SSc). Approximately 45 patients at approximately 40 sites will be randomized in a 2:1 ratio to receive either 10 mg/kg CM-101 or placebo.

Clinical Trial Description

This study will consist of a screening period, double-blind treatment period, open-label treatment period, and safety follow-up. Approximately 45 patients will be randomized in a 2:1 ratio to receive either 10 mg/kg CM-101 or placebo. The study drug or placebo, will be administered as a 60-minute intravenous (IV) infusion once every 3 weeks for a treatment coverage of 24 weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06210945
Study type Interventional
Source ChemomAb Ltd.
Contact
Status Suspended
Phase Phase 2
Start date September 2024
Completion date December 2026
View Details
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