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Vasculopathy, Inflammation and Systemic Sclerosis — VISS  

Systemic Sclerosis Clinical Trial

Official title:
Vasculopathy, Inflammation and Systemic Sclerosis: The Role of Endothelial Cell Activation and OX40/OX40L in Modulation of T Lymphocyte Activation

Clinical Trial Summary

It is a study of basic research with mechanistically objectives and including clinical biological samples.

Clinical Trial Description

Systemic sclerosis (SSc) is a rare and severe disease characterised by a fibrotic process and an incompletely elucidate physiopathology. Several shared featured have been identified between SSc and another autoimmune disease, the systemic lupus erythematous (SLE) as an interferon-alpha signature, the role of platelets and the polymorphism of OX40 ligand (OX40L). In SLE, OX40L has been shown highly linked to the active form of the disease, was increased by the CD40L of platelets and induced the CD8 cytotoxicity while inhibiting the suppressive functions of regulator T lymphocytes. The third main factor of the SSc physiopathology apart from autoimmunity and fibrosis is the vasculopathy with an important role of endothelial cells (EC). They turned out to be half-professional antigen presenting cells and can modulate the adaptive immunity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02562079
Study type Interventional
Source University Hospital, Bordeaux
Contact
Status Completed
Phase N/A
Start date March 2012
Completion date December 2016
View Details
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