Systemic Sclerosis Clinical Trial
Official title:
The Effect of Rosuvastatin on Vascular Dysfunction and Inflammatory Markers in Systemic Sclerosis-related Pulmonary Hypertension: Randomized, Double-Blind Placebo-Controlled Trial
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the
initial event and statins through their vasculoprotective effect might be of value in the
treatment armamentarium of PAH related to SSc.
The aim was to assess the efficacy of rosuvastatin in ameliorating vascular dysfunction and
in the management of SSc-related PAH.
Background: Pulmonary arterial hypertension (PAH) is an acknowledged devastating
complication of systemic sclerosis (SSc); difficult to manage with a poor prognosis.
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the
initial event.
Statins, through their pleotropic effects might be of value in the treatment armamentarium
of PAH related to SSc.
Objectives: The aim was to assess the efficacy of rosuvastatin in ameliorating vascular
dysfunction and in the management of SSc-related PAH.
Methods: Forty SSc patients fulfilling the ACR criteria for the classification of SSc
diagnosis and having PAH were recruited.
All SSc patients underwent transthoracic echocardiography and the six minute walk test
(SMWT).
Patients were randomized into 2 groups; the first group (n = 23) were assigned to receive
40mg of rosuvastatin and the second group (n = 23) received placebo for 6 months.
The levels of endothelial dysfunction and inflammatory markers were assayed at baseline and
after 6 months of therapy. Outcome measures assessed included exercise capacity (SMWT),
MPAP, WHO functional class change, tolerability and safety.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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