Syncope Clinical Trial
Official title:
Hypersensitive Troponin Performance to Identify Syncope at Risk of Serious Adverse Events in the Short Term
Syncope, a frequent reason for emergency room visits and hospitalization, is a symptom of three major etiological entities: cardiac causes, vaso-reflex causes and orthostatic hypotension. The etiological diagnosis is often uncertain and the prognostic assessment orients the outcome of the patient. The vast majority of syncope management costs are related to hospitalizations. Hospitalization in the immediate aftermath of emergency care is justified by a short-term prognosis. The current relevance of hospitalizations and the prognostic assessment of syncope is questioned.
The improvement of cardiac troponin assay techniques has increased its sensitivity to detect
myocardial ischemic conditions, even at the expense of a loss of specificity. Myocardial
infarction type 2 is due to an imbalance between needs and oxygen supply to cardiomyocytes at
the time of an increase of the first and / or a decrease of the second and is favored by an
underlying cardiovascular field fragile. Syncope, because of the low flow that they imply,
can be the cause of a type II myocardial infarction on fragile cardiovascular ground.
The study is prospectively conducted in all patients admitted for syncope to assess the
actual diagnostic performance of hypersensitive troponin in the syncope risk stratification.
The primary benefit is to identify patients at risk of serious cardiac events in the short
term. The secondary benefits expected from the study are a decrease in unjustified
hospitalizations of patients admitted to the emergency for syncope and thus a decrease in the
cost of care.
The validation of the indication of the troponin assay in the stratification of the risk
after a syncope passes by its prospective evaluation in a prognostic study.
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