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Clinical Trial Summary

SynABPM 2 proof-of-efficacy is a retrospective, multicentre, observational study performed in patients affected by hypotensive reflex syncope who had performed two ABPMs, one before and another after any therapeutical intervention aimed to increase arterial blood pressure


Clinical Trial Description

24-hour ambulatory blood pressure monitoring (ABPM) is able to detect systolic blood pressure (SBP) drops that allow to discriminate patients with reflex syncope from controls. One episode of daytime SBP <90 mmHg or one episode of daytime SBP <100 mmHg, if mean 24-hour SBP is <125 mmHg, is the best cut-off for the identification of reflex syncope patients with hypotensive susceptibility. The hypothesis of the present proof-of-concept study is that a therapeutic strategy aimed to increase arterial blood pressure can prevent SBP drops and (hopefully) reduce syncope recurrences. If the study hypothesis will be confirmed, the magnitude of increase of SBP needed to abolish SBP drops will be also assessed. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05729724
Study type Observational [Patient Registry]
Source Istituto Auxologico Italiano
Contact
Status Completed
Phase
Start date October 5, 2022
Completion date July 31, 2023

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