Surgical Wound Infection Clinical Trial
Official title:
Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections
Verified date | May 2019 |
Source | Johannes Gutenberg University Mainz |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.
Status | Completed |
Enrollment | 130 |
Est. completion date | May 14, 2019 |
Est. primary completion date | April 4, 2019 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - elective surgery of rectom, esophagus or liver with indication for a central venous catheter - informed consent Exclusion Criteria: - pregnancy - medical emergency - participation in another study |
Country | Name | City | State |
---|---|---|---|
Germany | Medical Center of the Johannes Gutenberg-University Mainz | Mainz | Rheinland-Pfalz |
Lead Sponsor | Collaborator |
---|---|
Johannes Gutenberg University Mainz |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum concentration of antibiotic | ug/mL | 2 days | |
Secondary | Surgical wound infection | Incidence | 30 days |
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