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Surgical Wound Infection clinical trials

View clinical trials related to Surgical Wound Infection.

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NCT ID: NCT03980652 Not yet recruiting - Clinical trials for Surgical Site Infection

Cheetah - Sterile Glove and Clean Instrument Change at the Time of Wound Closure to Reduce Surgical Site Infection

Cheetah
Start date: May 2020
Phase: N/A
Study type: Interventional

To assess whether the practice of using separate sterile gloves and instruments to close wounds at the end of surgery compared to current routine hospital practice can reduce surgical site infection

NCT ID: NCT03905213 Not yet recruiting - Cardiac Surgery Clinical Trials

Prevention of Surgical Wound Infection

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

To compare cost effectiveness of a polyurethane dressing or a vacuum therapy dressing versus the conventional gauze in the prevention of superficial wound infection y major cardiac surgery

NCT ID: NCT03872544 Not yet recruiting - Wounds and Injuries Clinical Trials

Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds

FTFDT3
Start date: September 20, 2023
Phase:
Study type: Observational

This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts work to repair wounds long term. Patients who have undergone free autologous dermal fat grafting to treat complex craniofacial wounds less than 1 week ago will have photographs and small biopsies taken of the area that was grafted. Patients will be followed for 2 years to monitor the area that was grafted.

NCT ID: NCT03853096 Not yet recruiting - Clinical trials for Surgical Site Infection

P.Acnes Colony Count Following Subdermal Cefazolin

Start date: April 1, 2019
Phase: Early Phase 1
Study type: Interventional

The specific outcome is to determine whether the colony count of Propionibacterium acnes, one of the commonest causes of shoulder infection and not eradicated by conventional forms of surgical preparatory solutions and antibiotics, in a shoulder surgical wound will be altered by the use of subdermal cefazolin.

NCT ID: NCT03736187 Not yet recruiting - Clinical trials for Surgical Site Infection

Antibiotics for Prevention of SSI in Obese Women Undergoing CS

Start date: April 2019
Phase: N/A
Study type: Interventional

Effect of cephalexin plus metronidazole on SSI better than cephalexin alone in obese women undergoing CS

NCT ID: NCT03226626 Not yet recruiting - Sepsis Clinical Trials

Tumescent Anesthesia Antibiotic Delivery (TAAD)

TAAD
Start date: December 1, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

This is a multicenter randomized clinical trial (RCT) comparing two modes of antibiotic delivery: Control: Intravenous Antibiotic Delivery (IVAD) Treatment: IVAD + TAAD The Food & Drug Administration (FDA) has approved our Investigational New Drug (IND) application to conduct this RCT. An IND application was necessary because subcutaneous injection of antibiotics in general, and cefazolin and metronidazole in particular are considered to be "off-label". In addition, the tumescent formulation of cefazolin (1gm) and metronidazole (500mg/100ml) in a dilute solution of lidocaine (1gm), epinephrine (1mg) in 100ml and sodium bicarbonate (10mEq/10ml) added a 1000ml bag of 0.9% sodium chloride (total volume 1210ml) is also considered "off-label." This trial will also prospectively study the HK Surgical SubQKath, an over-the-needle subcutaneous catheter specifically designed to deliver relatively large volumes of a relatively dilute TAAD solution. The TAAD trial will document the safety and efficacy of the HK SubQKath

NCT ID: NCT03144726 Not yet recruiting - Infection Clinical Trials

RCT on NPWT for Incisions Following Major Lower-limb Amputation to Reduce Surgical Site Infection

Start date: March 2018
Phase: N/A
Study type: Interventional

Surgical site infections following lower extremity amputations have been reported in up to 40% of patients. Surgical site infections have significant morbidity and even mortality in terms of emergency room visits, length of hospital stay, reamputation rates and death. Since its introduction, negative pressure wound therapy has been demonstrated to promote wound healing and possibly decreasing the need for future amputations. The aim of the study is to provide level I evidence for the use of negative pressure wound therapy devices in patients undergoing lower extremity amputation.

NCT ID: NCT02967627 Not yet recruiting - Clinical trials for Surgical Site Infection

VAC Dressings for Colorectal Resections

VACCRR
Start date: November 2016
Phase: N/A
Study type: Interventional

Surgical Site Infections (SSIs) and wound complications are common occurrences following colorectal resection surgery. Incisional Negative Pressure Wound Therapy (iNPWT) has developing evidence for improving wound complication rates in certain populations. However, there have been no RCTs to date that have looked at iNPWT use after colorectal surgery. We propose a study in which patients are randomized into one of two treatment arms: 1) incisional NPWT, and 2) standard sterile gauze dressings. Patients will be followed for 30 days for diagnosis of infection or wound complication. We will compare primary outcomes in each group using Chi-Squared statistical testing in order to report a Absolute Risk Reduction and Number Needed to Treat

NCT ID: NCT02779296 Not yet recruiting - Clinical trials for Surgical Wound Infection

Trial Investigating Cyanoacrylate Glue to Prevent Surgical Site Infection Following Breast Surgery

Start date: June 2016
Phase: Phase 4
Study type: Interventional

Surgical Site Infections (SSI) represents a significant complication in plastic surgery. Infections can result in a prolonged recovery and impair long-term cosmetic appearance. One potential method to reduce infection is by applying a thin layer of dermal glue over the sutures at the site of incision immediately after the surgery. Conventional closures, such as sutures or staples, leave the site vulnerable until epithelialization occurs in 24 to 48 hours. In contrast, dermal glue provides an instant, waterproof barrier and it has been shown to have intrinsic bacteriostatic properties. The glue is supplied as a liquid enclosed in a vial and when applied, polymerizes rapidly in an exothermic reaction in the presence of moisture to form a solid adhesive. 2-Octylcyanoacrylate (2-OCA)-based glue is formulated to be more flexible than previous preparations. The application of dermal glue is rapid, simple and requires no specific follow-up as it naturally sloughs off overtime. The purpose of this study is to determine if 2-OCA-based glue can reduce the rate of surgical site infection following surgery. Patients undergoing breast surgery will be recruited and randomized to either a group receiving a layer of glue over sutures following surgery or no treatment. Patients will be followed up at 30 days and at 8 months for signs of infection, additional complications and the visual appearance of the scars. The cost of treating and infection will be calculated to determine if using dermal glue to prevent infection is economically feasible. This research has the potential to find a method to reduce surgical site infection, which can be applied to other surgeries.

NCT ID: NCT02503904 Not yet recruiting - Clinical trials for Venous Thromboembolism

Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection

Start date: October 2015
Phase: Phase 2/Phase 3
Study type: Interventional

The principal aim of the present research is to compare two methods of antibiotic delivery: concomitant tumescent antibiotic delivery (TAD) and intravenous antibiotic delivery (IVAD) versus IVAD alone, (TAD+IVAD vs IVAD), with respect to the prevention of surgical site infections (SSI). The investigators hypothesize that TAD+IVAD will significantly reduce the incidence of SSI compared to IVAD. TAD is the subcutaneous infiltration of a dilute solution of antibiotic(s) in a solution of tumescent local anesthesia (TLA). TLA consists of a dilute solution of lidocaine (1gm/L), epinephrine (1mg/L) and sodium bicarbonate (10mEq/L) in 0.9% physiologic saline. A secondary aim of this study is to compare TAD+IVAD vs IVAD with respect to the prevention of post-operative venous thromboembolism (VTE).