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Surgical Site Infection clinical trials

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NCT ID: NCT05434182 Recruiting - Clinical trials for Surgical Site Infection

Intradermal Suture Versus Stapling for Groin Skin Closure in Vascular Surgery (VASC-INF Trial)

Start date: March 4, 2022
Phase: N/A
Study type: Interventional

Surgical site infection (SSI) is one of the most frequent and fearsome complications in vascular surgery due to its high morbidity and mortality. In addition, SSI is one of the factors related to the development of prosthetic infection. Consequently, it represents a significant increase in hospital stay and healthcare costs. A 2021 meta-analysis on groin SSI prevention strategies in arterial surgeries reported that using intradermal sutures could be associated with a lower SSI rate. The published results from a single-center retrospective study comparing SSI rates before and after implementing an SSI prevention protocol also suggest better outcomes with intradermal suturing. This study aims to assess the SSI incidences of both skin closure techniques in vascular surgery patients undergoing femoral artery approach through a perpendicular groin skin incision.

NCT ID: NCT05371938 Recruiting - Surgery Clinical Trials

Volar Locking Plate Versus External Fixation for Distal Radius Fracture - a Longterm Follow up

EXTEND
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

A 10-year follow up of a fusion of two earlier published randomized controlled trials. 203 patients with displaced distal radius fractures were randomized to surgery with a volar locking plate or external fixation.

NCT ID: NCT05260463 Recruiting - Clinical trials for Surgical Site Infection

LOQTEQ® Antibacterial Pre-Market Study

Start date: December 9, 2021
Phase: N/A
Study type: Interventional

aap001 is a randomized, controlled, subject-blinded, multi-center study to show the safety of the LOQTEQ® antibacterial silver-coated system is non-inferior in comparison with the uncoated LOQTEQ® system

NCT ID: NCT05077592 Recruiting - Clinical trials for Surgical Site Infection

Addition of Pre-wound Closure Povidone Iodine Wash Versus Direct Wound Closure Effect on Surgical Site Infections

Start date: September 18, 2021
Phase: Phase 4
Study type: Interventional

A Randomized controlled trail to To assess the efficacy of povidone-iodine wash before wound closure in preventing surgical site infections.

NCT ID: NCT05040399 Recruiting - Clinical trials for Surgical Site Infection

Sternal Wound Infection in Patients Undergone Sternal Fixation Using Locking Compression Plates

Start date: April 20, 2019
Phase: N/A
Study type: Interventional

Sternal Wound Infection (SWI) in open heart surgery is one of the most annoying and avoidable complications that one encounters during work. Investigators investigate the rates of sternal wound infection (SWI) in patients in whom were used locking compression plates (LCP) versus in patients in whom were used wires to fixate the sternum for variable causes. SWI increases the overall cost and burden in the medical service and increases the patients suffering and disability. investigators aim to provide our patients with the most suitable means for sternal fixation.

NCT ID: NCT04986111 Recruiting - Clinical trials for Surgical Site Infection

The Efficacy of Purse-string Skin Closure With Negative Pressure Wound Therapy (NPWT) After Ileostomy Reversal

Start date: January 25, 2021
Phase: N/A
Study type: Interventional

Evaluating the effectiveness of the existing 'linear suture + wound drain placement' and 'purse-string suture + negative pressure wound therapy' through a prospective comparative study

NCT ID: NCT04975945 Recruiting - Clinical trials for Surgical Site Infection

Assessing Parenteral Antibiotics Versus Single-time Intra-operative Intra-dermal Antibiotic Administration for Prevention of SSI

Start date: August 2021
Phase: Phase 4
Study type: Interventional

The purpose of the study is to study the incidence of surgical site infection when patients are given local versus parenteral antibiotics

NCT ID: NCT04964947 Recruiting - Clinical trials for Surgical Site Infection

Tobramycin Injection to Prevent Infection in Open Fractures

Start date: January 10, 2022
Phase: Phase 3
Study type: Interventional

The goal of open extremity fracture (OEF) treatment is to promote fracture healing and restore function while preventing the development of infection. This is achieved through systematic and timely wound debridement and irrigation, fracture stabilization, tetanus prophylaxis, systemic and local antimicrobial therapy, and judicious timing of wound closure based on cleanliness. Early prophylactic systemic antibiotics lower infection rates in open fractures but have limitations of achieving adequate concentration at the hypoperfused wound area. OEF wounds are frequently poor in vasculature secondary to the soft tissue injury, hence adequate concentration of antibiotic cannot permeate to the tissue at risk. If systemic antibiotic concentrations are increased to achieve minimum inhibitory concentration (MIC) for pathogens at the wound, there is heightened concern for systemic drug toxicity. In sharp contrast, locally administered antibiotics achieve high drug concentration directly within the wound cavity with minimal systemic side effects. Local antibiotic therapy has shown to reduce rates of open fracture wound infection. With the serious implications of postoperative infections in OEF, it is imperative that all measures including further use of prophylactic local antibiotics be considered to prevent fracture-related infection (FRI). The overarching hypothesis for this project is that a novel synergistic combination of local aqueous tobramycin plus perioperative weight-based IV cephalosporin antibiotic prophylaxis will reduce the rate of FRI one year after OEF surgery. This in turn will improve OEF patient outcomes, decreasing morbidity and return to the operating room (OR) without any adverse effect on fracture healing. Regardless of the treatment group, bacterial speciation will be determined for patients that do develop FRI to help guide future treatment. The goal is to improve the clinical outcome and recovery of the population that sustains an OEF by decreasing the rate of FRI and fracture nonunions while concurrently educating on bacterial speciation and resistance.

NCT ID: NCT04860570 Recruiting - Clinical trials for Surgical Site Infection

Are Double-ring Wound-edge Protectors Effective for Preventing Superficial Surgical Site Infection After Open Appendectomy?

sSSI-2RWEPs
Start date: October 25, 2024
Phase:
Study type: Observational

This study aims to evaluate the utility of double-ring wound-edge protectors to prevent the development of superficial surgical site infections after open appendectomy.

NCT ID: NCT04773457 Recruiting - Clinical trials for Surgical Site Infection

Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

Start date: April 1, 2023
Phase:
Study type: Observational

Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.