Lumbar Erector Spinae Plane Block for Back Surgery

Surgery Clinical Trial

— LUMBES  

Official title:

A Prospective Randomized Double Blind Trial of the Efficacy of a Bilateral Lumbar Erector Spinae Block on the 24h Morphine Consumption After Posterior Lumbar Interbody Fusion Surgery.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03825198
• Other study ID #: B300201837508
• Status: Recruiting
• Phase: Phase 3
• Start date: August 1, 2019
• Est. completion date: December 15, 2023

Study information

• Verified date: August 2022
• Source: University Hospital, Antwerp
• Contact: margaretha breebaart, MD PhD
• Phone: 003238213865
• Email: margaretha.breebaart[@]uza.be
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Title:

A prospective randomized double blind trial of the efficacy of a bilateral lumbar erector spinae block on the 24 h morphine consumption after posterior lumbar interbody fusion surgery.

Objectives:

The primary objective is to study the influence of a bilateral erector spinae block on 24h morphine consumption.

Endpoint:

The primary endpoint is the 24 h morphine consumption in mg. Secondary endpoints are intraoperative sufentanil requirement, total morphine during first 72 postoperative hours, NRS pain scores in rest and defined movement (moving to chair) at regular time intervals and Quality of Recovery 40 score (QoR-40) at fixed time intervals day 1 and 3 postoperatively

Population:

Patients undergoing posterior lumbar interbody fusion ranging 1 - 3 levels Phase 3

Number of sites Enrolling participants:

University Hospital Antwerp &AZ KLINA Brasschaat

Description of study agent:

Bilateral erector spinae block: each block contains 20 ml levobupivacaine 0.25% + 5 mcg/ml epinephrine Study duration Until the required study population is met Participant duration 72 hours

Description:

In this prospective randomized double blind placebo controlled clinical trial we would like to assess the efficacy of a bilateral lumbar erector spinae block on the 24h morphine consumption after posterior lumbar interbody fusion surgery. Patients scheduled for 1-2 level PLIF surgery will be recruited in AZ KLINA in Brasschaat and the University Hospital Antwerp in Edegem. The study contains two arms. Subjects will be randomly allocated to an erector spinae block group or the sham block group (placebo).

Stratified randomization will be done according to gender, levels of surgery and site online with Q minim.The study medication will be prepared in identical premade syringes and numbered according to a computer generated block randomization list (1:1 ratio ESB:sham). Subjects will be assigned consecutive numbers upon inclusion to the study and receive the study medication from the corresponding numbered syringes. The study medication in syringes for injection will be prepared by an anesthesiologist neither involved in the study nor in the care of the patient, before handing it over to the investigators. The ESB-group will receive 20 ml Chirocaine 0,25%. The sham block group medication will receive 20 ml Nacl0,9%. The levobupivacaine and saline 0.9% are identical in appearance. All investigators, staff and patients will be blinded to the treatment groups. Epinephrine is added to the placebo block in order to prevent unblinding by increased heart rate or blood pressure. Unmasking will not occur until statistical analysis is complete.

Patients in the erector spinae block group will receive a bilateral ESB block with an injectate containing 20 ml of levobupivacaine 0.25% in each puncture. Patients allocated to the sham group receive a bilateral ESB block with each injectate containing 20 mL of NaCl 0.9% . The blocks will be performed by experts in the field of ultrasound guided locoregional anaesthesia namely dr D. van Aken, dr L. Sermeus and dr M.B. Breebaart who are also teachers for the BARA (Belgian Association of Regional Anaesthesia). The blocks will be performed preoperatively in a separate block room with ultrasound after placement of an iv line and application of standard monitoring (ECG, NIBP, saturation). The blocks will be placed as described by Chin et al. modified for lumbar level.8 First, the patient will be placed in the lateral or sitting position. A curve array probe or a high frequency linear probe, depending on the BMI of the patient, will be placed in a longitudinal position 2-3 cm lateral of the vertebral column. The transverse processes of the vertebrae at the (mid) level of surgery, the erector spinae muscle and the psoas muscle are identified. In case of two level surgery the transverse process of the upper level will be considered as the preferred target. Depending on the depth a 5 or 8 cm 22 G ultrasound needle (Pajunk) will be inserted with an in plane technique in a cephalad to caudad direction until bone contact with the top of the transverse process is reached. After slight retraction of the needle, 20 ml of the study medication will be injected behind the erector spinae muscle. The same procedure will be repeated on the contralateral side.

General anesthesia will then be induced in a standardized way with propofol 2-3mg/kg, sufentanil 15mcg and rocuronium 0.5mg/kg. After tracheal intubation anesthesia will be maintained with sevoflurane and intraoperative analgesia with sufentanil. The dosages of these agents will be determined at the discretion of the anesthesiologist. At the end of surgery patients will receive acetaminophen 1g IV, ketorolac (Taradyl, CSP Benelux) 0.5 mg/kg (max. 30 mg) IV and a morphine loading dose (0.1 mg/kg) IV to manage postoperative pain. Patients will be extubated in the operating theatre and admitted to the post anesthesia care unit (PACU). Postoperative pain in the PACU and on the ward will be treated with acetaminophen 1g IV round the clock (4 times daily) and by a patient controlled intravenous analgesia pump (PCIA) with morphine at a concentration of 1 mg/ml and dehydrobenzperidol (DHBP) 0.05 mg/ml. The PCIA will be set using a standardised protocol: no background administration of morphine, a bolus dose of 1.5 mL morphine with a lock-out interval of 8 minutes and an hourly limit of 7.5 mg. If pain management on the PACU is inadequate (NRS > 3) additional boli of 1 mg morphine IV will be administered with the total additional dose of morphine limited to 0.15mg/kg morphine. In case NRS is still > 3 an IV ketamine (Ketalar, Pfizer) bolus (0.2 mg/kg) will be given. All patients receive dexamethasone 5mg IV as postoperative nausea and vomiting (PONV) prophylaxis. If needed, this will be supplemented by ondansetron 4mg IV and if still insufficient with alizapride 50mg IV. Other study endpoints will be retrieved from the patient data management systems

The morphine consumption during the first 24 hours postoperatively will be extracted out of the PCIA pump. The total morphine dose requirement during the first 72 postoperative hours will also be extracted out of the PCIA pump. Pain scores at rest will be assessed with the numeric rating scale (NRS, 0=no pain 10= worst imaginable pain) and tested at regular time intervals: at the time of inclusion, at the PACU (T0 = arrival at Post Anesthesia Care Unit, T+15min, T+30min) and ward (twice daily- morning and evening until postoperative day 3) Pain scores during defined movement (first moving to chair and upright sitting) will be examined. Time to first mobilization in chair (in hours since T0) and time to first walk of twenty meters (in hours since T0) will be noted in the patients study diary. The quality of recovery 40 score (QoR-40) will be calculated out of a series of questions patients are required to answer at day 1 and 3 postoperatively. The QoR-40 is a widely used and extensively validated measure of quality of recovery. It is a 40-item questionnaire on quality of recovery from anesthesia, that has been shown to measure health status after surgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: December 15, 2023
• Est. primary completion date: December 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• - Patients scheduled for 1-2 level posterior lumbar interfusion surgery in AZ KLINA Hospital or University of Antwerp Hospital (UZA) after approval of Ethical Committee until all required patients are included

• American Society of Anesthesiologist (ASA) score of 1 - 3

• Age 18 - 75 year

• Normal liver and renal function

Exclusion Criteria:

• Age <18 years or mentally incompetent

• BMI < 16 or BMI > 35

• Allergy to one or more substances of the study medication (= levobupivacaine, dexamethasone, propofol, sufentanil, rocuronium, ketorolac, morphine, ketamine, DHBP, ondansetron, alizapride)

• Chronic strong opioid use (>3 intakes per week)

Related Conditions & MeSH terms

• Anaesthesia
• Anesthesia, Local
• Back Pain
• Nerve Block
• Pain, Postoperative
• Spinal Fusion
• Surgery

Intervention

Procedure:
• Erector spinae plane block
Ultrasound guided deposition infiltration between a lumbar transverse proces and the erector spine muscle

Drug:
• Levobupivacaine 0,25%
20 ml levobupivacaine 0,25% used for the infiltration between the transverse process and the erector spinal muscle

Procedure:
• spine fusion
fusion of lumbar vertebral body on 1 or two levels

Drug:
• NaCL 0,9%
20 ml solution used for the infiltration between the transverse process and th erector spinal muscle
• Sufentanil
opioid used for the preoperative analgesia for back surgery during general anaesthesia ( 15 mag)
• propofol
induction agent for general anaesthesia ( 2-3 mg/kg)
• Rocuronium Bromide
muscle relaxant used during general anaesthesia ( 0,5 mg/kg)
• sevoflurane
inhalation aesthetic used for the maintenance of general anaesthesia
• paracetamol
postoperative drug for analgesia ( 1 gram 4/day)
• Ketorolac
non steroidal into inflammation drug used for postoperative analgesia (0,5 mg/kg)
• morphine pca
postoperative morphine pomp, controlled by the patient. ( bolus 1 mg, lockout 8 minutes) the solution contains morphine 1 mg/ml + dehydrobenzperidol 0,05 mg/ml
• Dexamethasone
drug given during general anaesthesia to prevent postoperative nausea
• Morphine
loading dose morhine 0,1 mg/kg at the end of surgery

Locations

Country	Name	City	State
Belgium	University Hospital Antwerp	Antwerp
Belgium	AZ KLina	Brasschaat	Antwerp

Sponsors (1)

Lead Sponsor	Collaborator
Dr M. B. Breebaart

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	expected preoperative pain score (NRs°	Numeric rating scale pain score (in numbers). pain that people expect before they have surgery.	before surgery ( moment of inclusion)
Primary	24 hour morphine consumption	total milligrams (0-150) of morphine used in the first 24 hours after surgery, extracted out of the pca pump data.	24 hours
Secondary	Intraoperative sufentanyl requirement (	total Intravenous administered sufentanyl in micrograms during surgery(10-100)	2-5 hours
Secondary	Morphine consumption 72 hours	total milligrams of morphine used in 72 hours after surgery (0-450), extracted out of the pca pump data	72 hours
Secondary	NRS pain scores	Numeric rating scale pain score (in numbers) and rest (0= no pain10 =worst thinkable pain)	at regular intervals and defined movement until 72 hours after surgery
Secondary	Quality of recovery score (QoR-40)	score in numbers of mental and psychological well being scored by list of questions (minimal score 20-maximum score 200). A high score indicates a better/faster recovery, and is inversely correlated with hospital stay	day 1 and day 3 postoperatively
Secondary	time to mobilisation to chair	movements (mobilisation to chair) in hours after surgery	8-72 hours
Secondary	time to 20 meter walking	movement 20 meter walking in hours after surgery	8-72 hours