Fluid Administration Limited by Lung Ultrasonography in the Operating Room: Correlation to Stroke Volume Variation.

Surgery Clinical Trial

— ORFALU  

Official title:

Fluid Administration Limited by Lung Ultrasonography in the Operating Room: Correlation to Stroke Volume Variation (ORFALU)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03502460
• Other study ID #: PI2017_843_0018
• Status: Completed
• Phase: N/A
• Start date: May 31, 2018
• Est. completion date: October 30, 2019

Study information

• Verified date: January 2020
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The possibility of exploring the lungs by lung ultrasound, a non-invasive tool, is becoming increasingly popular for anesthesiologists. Recently, Lichtenstein has described the FALLS protocol (Fluid Administration Limited by Lung Sonography) which uses the potential of pulmonary ultrasound to evaluate early pulmonary overload due to fluid administration at a subclinical stage. Indeed, fluid administration can generate a sub-clinical interstitial syndrome that can be detected by passing from a profile A to a profile B in lung ultrasound. The transition from a profile A to a profile B therefore corresponds to the transition from a state of preload dependent to a state of preload independence. However, this tool has not been studied in the operating room. The main objective of this study will be to study the correlation between pulmonary ultrasound and SV variation measured by esophageal Doppler during fluid administration in patients with haemodynamic optimisation in the operating room during digestive, urological, gynecological and orthopedic surgeries. The main expected result is the following: good correlation between the absence of increased SV in the esophageal Doppler and the appearance of a B-profile lung ultrasound fluid administration in the operating room.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 200
• Est. completion date: October 30, 2019
• Est. primary completion date: October 30, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age = 18 ans

• inclusion criteria:

• Patient having a digestive, urological, gynecological, vascular or orthopedic surgery

• Haemodynamic optimisation requiring titration of the fluid administration

• Informed consent signed

Exclusion Criteria:

• Non-consent

• Chronic pulmonary pathology: COPD with pulmonary emphysema, pulmonary fibrosis

Related Conditions & MeSH terms

• Stroke
• Surgery

Intervention

Other:
• Operating Room Fluid Administration Lung Ultrasound
Use of lung ultrasound to limited fluid administration

Locations

Country	Name	City	State
France	CHU Amiens	Amiens

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Apparition of Lines B at Lung Ultrasonography		1 day