Surgery Clinical Trial
Official title:
Neoadjuvant Therapy for Locally Advanced Esophageal Cancer: Impact on Cardiopulmonary Physiology, Short- and Long-term Morbidity
Although recent global trends indicate reduced postoperative mortality after esophagectomy,
major morbidity, in particular pulmonary, remains high, with considerable health and economic
costs. In a recent modern international collaborative series of 2704 patients from
high-volume centers, with an approximate equal mix of open and minimally invasive approaches,
respiratory complications were evident in 28% of patients, pneumonia in 15%, and respiratory
failure in 7%.1 In other series, respiratory failure is reported in up to 15% of patients and
is the most common cause of mortality. Prediction of risk and prevention of respiratory
morbidity is therefore of considerable importance, and in this context baseline assessment of
respiratory physiology compliments clinical assessment, history and enhanced recovery
pathways representing key elements of current patient management.
In this study, which will include all prospective patients with locally advanced esophageal
cancer treated at a National Center, pulmonary function will be systematically measured
before and after neoadjuvant therapy. The investigators seek to evaluate the incidence of
radiation induced lung injury (RILI), as well as subclinical changes in pulmonary physiology
that may be linked to postoperative complications, and quality-of-life in survivorship, and
to compare cohorts who received radiation therapy or chemotherapy alone, preoperatively.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05583916 -
Same Day Discharge for Video-Assisted Thoracoscopic Surgery (VATS) Lung Surgery
|
N/A | |
| Completed |
NCT04448041 -
CRANE Feasibility Study: Nutritional Intervention for Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries
|
||
| Completed |
NCT03213314 -
HepaT1ca: Quantifying Liver Health in Surgical Candidates for Liver Malignancies
|
N/A | |
| Enrolling by invitation |
NCT05534490 -
Surgery and Functionality in Older Adults
|
N/A | |
| Recruiting |
NCT04792983 -
Cognition and the Immunology of Postoperative Outcomes
|
||
| Terminated |
NCT04612491 -
Pre-operative Consultation on Patient Anxiety and First-time Mohs Micrographic Surgery
|
||
| Recruiting |
NCT06397287 -
PROM Project Urology
|
||
| Recruiting |
NCT04444544 -
Quality of Life and High-Risk Abdominal Cancer Surgery
|
||
| Completed |
NCT04204785 -
Noise in the OR at Induction: Patient and Anesthesiologists Perceptions
|
N/A | |
| Completed |
NCT03432429 -
Real Time Tissue Characterisation Using Mass Spectrometry REI-EXCISE iKnife Study
|
||
| Completed |
NCT04176822 -
Designing Animated Movie for Preoperative Period
|
N/A | |
| Recruiting |
NCT05370404 -
Prescribing vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients With Postoperative Pain:
|
N/A | |
| Not yet recruiting |
NCT05467319 -
Ferric Derisomaltose/Iron Isomaltoside and Outcomes in the Recovery of Gynecologic Oncology ERAS
|
Phase 3 | |
| Recruiting |
NCT04602429 -
Children's Acute Surgical Abdomen Programme
|
||
| Completed |
NCT03124901 -
Accuracy of Noninvasive Pulse Oximeter Measurement of Hemoglobin for Rainbow DCI Sensor
|
N/A | |
| Completed |
NCT04595695 -
The Effect of Clear Masks in Improving Patient Relationships
|
N/A | |
| Recruiting |
NCT06103136 -
Maestro 1.0 Post-Market Registry
|
||
| Completed |
NCT05346588 -
THRIVE Feasibility Trial
|
Phase 3 | |
| Completed |
NCT04059328 -
Novel Surgical Checklists for Gynecologic Laparoscopy in Haiti
|
||
| Recruiting |
NCT03697278 -
Monitoring Postoperative Patient-controlled Analgesia (PCA)
|
N/A |