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Clinical Trial Summary

Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.


Clinical Trial Description

Brain parenchyma express tissue factor and other coagulation factors in high concentrations. In addition, neuro critical patients (NCP) may present platelet dysfunction, hyperfibrinolysis, hypo coagulation and / or hyper coagulation status, early after the injury. It is not known whether these alterations of hemostasis are due to a specific brain response to aggression, or they are included into a systemic response. This prospective, observational study is aimed to investigate the coagulation disorders specifically associated with cerebral aggression.

This is a prospective, cohort study including (calculated sample size) a study group of patients undergoing elective surgery (glial tumors) and other one undergoing colo rectal surgery. Alterations of the hemostasis will be evaluated by clotting tests, thromboelastometry and tests for platelet function. Samples will be drawn before and after surgical procedures. Multiple statistical comparisons intra and inter groups will be performed. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02652897
Study type Observational
Source Hospitales Universitarios Virgen del Rocío
Contact Santiago R. Leal-Noval, MD Ph.D
Phone 0034955012528
Email srlealnoval@gmail.com
Status Recruiting
Phase
Start date May 2016
Completion date March 2019

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