Surgery Clinical Trial
Official title:
S.O.S. Ventilation - Sedation Optimisation Strategy For Mechanical Ventilation In Intensive Care Unit Patients
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and atraumatic mechanical ventilation. However, sedation excess and ventilator support excess, both in duration and intensity, are associated with an excess morbidity. Patients usually are systematically sedated after having been intubated. Then, sedation is stopped first before ventilator support is weaning. Several studies shown that rationalized protocols of sedation and ventilation orderings had a beneficial impact on non surgical patients' outcome. Feasibility of these protocols in surgical patients is still unknown. Moreover, no study has evaluated an optimized paired strategy of sedation-ventilation based on the priority setting of ventilation. This priority setting of ventilation should increase patient's comfort in spite of increasing sedatives and analgesics dosing. An paired sedation-ventilation protocol optimized for both duration and intensity of these treatments could improve surgical patients' outcome in ICU.
Intervention group:
- Continuous use of sedatives and analgesics (commonly called "sedation") will be stopped
upon enrolment.
- Ventilator asynchrony in Volume assist Controlled Ventilation (VCV) will be treated by
switching to Pressure Support Ventilation (PSV) or adjusting setting of VCV.
- Pain, anxiety and agitation will be treated by priority setting of the mechanical
ventilator aimed to deliver the most comfortable ventilator support and secondly by
adding analgesics and/or psychoactive drugs without inducing a coma state.- Persistent
ventilator asynchrony or persistent agitation will be treated by 6-hours continuous
sedation periods.
- Extubation will be performed according to criteria defined by the national consensus on
mechanical ventilation weaning, which are based on a daily spontaneous breathing trial
in the absence of any sedation.
Control group (standard practices):
- Continuous use of sedatives and analgesics (commonly called "sedation") will be daily
stopped according to criteria defined by the national consensus on sedation for ICU
patients.- During the period before the interruption of sedation, ventilator asynchrony
in VCV will be treated by increasing the depth of sedation and then the dose of
opioids.
- During the period before the interruption of sedation, pain, anxiety and agitation will
be treated by a priority adjustment of sedation according to the nurse driven protocol
recommended by the national consensus on sedation for ICU patients.- During the period
after the interruption of sedation, ventilator asynchrony will be treated by switching
to the PSV mode. In case of return to VCV, asynchrony will be treated by restart of
sedation.
- During the period after the interruption of sedation, pain, anxiety and agitation will
be treated as for the intervention group.
- Extubation will be performed according to criteria defined by the national consensus on
mechanical ventilation weaning, which are based on a daily spontaneous breathing trial
in the absence of any sedation.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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