Surgery Clinical Trial
Official title:
A Randomized Controlled Clinical Trial Evaluating the Efficacy of Silverlon® in Preventing Surgical Site Infection Following Colorectal Surgery
This clinical study is a prospective, randomized, controlled trial of patients undergoing
elective colorectal surgical procedures that receive an abdominal skin incision of at least
6 cm. Treatment with Silverlon® will be compared to standard postoperative dressings of 4x4
Gauze and paper tape. Patients will be randomized with a 1:1 treatment allocation ratio to
receive either 1) Silverlon® or 2) standard postsurgical dressing. Neither the Investigators
nor the participants will be blinded to the treatment modality after randomization.
Silver has long been known to have antimicrobial properties. It interacts with structural
proteins and DNA, inhibiting bacterial replication and causing fatal structural changes
within the cell wall. It has broad antimicrobial activities and unlike antibiotics, it is
rarely associated with microbial resistance. Silverlon® is a silver-nylon dressing
specifically designed for surgical wounds to prevent the development of surgical site
infections. It is an easy to use product with no known microbial resistance or adverse
effects. The efficacy of Silverlon® in preventing surgical site infections has been shown in
several retrospective studies but as of yet has not been tested in a prospective fashion.
The objective of this study is to perform a prospective, randomized, clinical trial directly
comparing the incidence of surgical site infections in patients treated with Silverlon® to
standard postoperative dressing following elective colorectal surgery
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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