Stroke Clinical Trial
Official title:
Effect of Dual-task Training on the Number of EEG Band in Stroke Patients
Stroke is a prevalent global health concern, causing widespread disability as it disrupts blood supply to the brain, leading to functional impairments. Upper limb dysfunction affects over 80% of stroke survivors acutely and becomes permanent in approximately 60%, hindering daily activities and autonomy. Dual-task training (DTT), involving simultaneous cognitive and motor tasks resembling daily activities, is proposed as an effective intervention. The study suggests using electroencephalogram (EEG) analysis, particularly the Fast Fourier Transform (FFT), to assess changes in brain signals pre- and post-DTT intervention. EEG provides real-time insights into brain function, and FFT analyzes signal frequencies. The intervention involves three tasks performed concurrently with mental calculations, such as sorting blocks and manipulating objects. This 12-session, four-week intervention aims to improve upper limb function. The study explores EEG's role in evaluating DTT effects on stroke patients, particularly using FFT to analyze brain signal frequencies.
Status | Not yet recruiting |
Enrollment | 5 |
Est. completion date | May 29, 2024 |
Est. primary completion date | April 29, 2024 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 35 Years to 75 Years |
Eligibility | Inclusion Criteria: - Unilateral stroke proven by imaging evidence - Women between 35 and 75 years old - At least six months have passed since the onset of the stroke Exclusion Criteria: - Suffering from another neurological or orthopedic disease - Score greater than 3 on the modified modified Ashworth scale in the upper limb - Having received a botulinum toxin injection before or during the course of the study - History of brain surgery - Be using medication that may alter cortical activity or brain plasticity or aimed at reducing the level of spasticity. |
Country | Name | City | State |
---|---|---|---|
Iran, Islamic Republic of | Shahid Beheshti University of Medical Sciences | Tehran | Velenjak |
Lead Sponsor | Collaborator |
---|---|
Universidad de Zaragoza |
Iran, Islamic Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | EEG Data | EEG data will be collected both before and after intervention, under the supervision of a neurologist, with the participant in a resting state and eyes closed. EEG recording will be carried out during 3 minutes with 10-20 system, 19 electrodes (Fp1, Fp2, F7, F3, Fz, F4, F8, T7, C3, Cz, C4, T8, T10, P3, Pz, P4, P8, T9, P7) and a sampling rate of 256 Hz. Frequencies below 1Hz and above 40Hz will be filtered. One of the three minutes of EEG collection will be randomly selected, and analysis will be carried out for that minute only. Before data analysis, abnormal waves such as blinking and electromyographic signals will be removed. All these operations will be carried out in MATLAB and by EEGLab toolbox. | Before and after intervention (4 weeks) | |
Secondary | Upper limb function | Upper limb function will be measure with the "Box and Block test", which is a functional test to specifically measure unilateral manual dexterity including grasping, carrying and releasing objects, consisting of transferring 150 coloured wooden cubes, each measuring 1 inch, from one box to another as quickly as possible within 60 seconds using only the affected hand. | Before and after intervention (4 weeks) | |
Secondary | Elbow flexor muscle tone | Elbow flexor muscle tone will be measured with the modified modified Ashworth scale, scored on an ordinal scale from 0 to 4: 0 = no increase in muscle tone; 1 = slight increase in muscle tone, manifested by a catch and release or minimal resistance at the end of the range of motion when affected part is moved in flexion or extension; 2 = a marked increase in muscle tone, manifested by a catch in the middle range and resistance throughout the remainder of the range of motion, but the affected part easily moved; 3 = considerable increase in muscle tone, passive movement difficult; and 4 = affected part rigid in flexion or extension | Before and after intervention (4 weeks) | |
Secondary | Wrist extension range of motion | Wrist extension range of motion will be measured with a goniometer | Before and after intervention (4 weeks) | |
Secondary | ADLs | The functional assesment of the patient in ADLs will be measured with the Barthel Index, which is a scale that scores ten basic aspects of activity related to self-care and mobility (bowels, bladder, grooming, toilet use, feeding, transfer, mobility, dressing, stairs and bathing) from 0 to 100 where lower scores indicate greater dependency | Before and after intervention (4 weeks) |
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