Stroke Clinical Trial
Official title:
Efficacy of Individualized Repetitive Transcranial Magnetic Stimulation Based on Cortical Laterality for Motor Recovery in Stroke Patients
This study aimed to aim to investigate the efficacy of individualized rTMS according to lateralization index on motor recovery and cortical excitability in subacute stroke patients.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | May 20, 2027 |
Est. primary completion date | May 20, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: 1. Unilateral ischemic or hemorrhagic stroke 2. Stroke within 3 months 3. Medical Research Council Scale for Muscle Strength in upper limb = 3 4. No previous stroke, seizure, dementia, Parkinson's disease or other degenerative neurological diseases. 5. Patient could sit over 15 minutes 6. Age over 20 Exclusion Criteria: 1. Previous stroke, traumatic brain injury, brain tumor 2. With central nervous system disease (spinal cord injury, Parkinson's disease) 3. Any contraindication to rTMS (seizure, alcoholism, metal implant, pacemaker) 4. Patients unable to cooperate the treatment 5. Pregnancy 6. Depression |
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei county | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Fugl-Meyer Assessment | Fugl-Meyer Assessment motor function set, score: 0-66, higher scores indicate a better outcome. | 12 weeks post intervention | |
Secondary | Medical Research Council (MRC) Scale for Muscle Strength | Medical Research Council (MRC) Scale for Muscle Strength, assessing muscle strength from Grade 5 (normal) to Grade 0 (no visible contraction). | 1 week, 4 weeks, 12 weeks post intervention | |
Secondary | National Institutes of Health Stroke Scale | National Institutes of Health Stroke Scale, The maximum possible score is 42, with the minimum score being a 0. Higher scores indicate a worse outcome. | 1 week, 4 weeks, 12 weeks post intervention | |
Secondary | Barthel Index | Barthel Index, score 100-0. Higher scores indicate a better outcome. | 1 week, 4 weeks, 12 weeks post intervention | |
Secondary | Modified Rankin Scale | Modified Rankin Scale, score from 0 to 6. Higher scores indicate a worse outcome. | 1 week, 4 weeks, 12 weeks post intervention | |
Secondary | MEP | motor evoked potential | 1 week, 4 weeks, 12 weeks post intervention | |
Secondary | Fugl-Meyer Assessment | Fugl-Meyer Assessment motor function set, score: 0-66, higher scores indicate a better outcome. | 1 week, 4 weeks post intervention | |
Secondary | functional NIRS | Functional Near Infrared Spectroscopy to detect the cortical excitability | 1 week, 4 weeks, 12 weeks post intervention |
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