Modulation of Cortical Gamma Synchrony in Stroke — GAMMASTROKE  

Stroke Clinical Trial

Official title: Assessment and Modulation of Cortical Gamma Synchrony to Predict and Improve Stroke Recovery

Status Recruiting

Clinical Trial Summary

In the last decades, the research in neuroimaging-informed stroke prognosis and treatment has had a little clinical impact, often because of the costs of bringing complex procedures to the bedside. Cerebral stroke remains the leading cause of disability, with 65% of survivors chronically impaired at 6 months. Gamma synchrony (GS) is a fundamental mechanism of cortical function and can be estimated and modulated in a simple, inexpensive, and reliable way. It has provided valuable and cost-effective guidance in several neuropsychiatric conditions. In previous studies, we developed simple yet robust methods for assessing and manipulating GS and proved its relationship with clinical impairment in preliminary data.

The aim of the present project is to predict and improve stroke recovery by leveraging cortical mapping and modulation of GS via transcranial alternating current stimulation (tACS), a safe and inexpensive technique. The project capitalizes on technology readily available to the Italian national health system.

Clinical Trial Description

The project will consist of 3 Work Packages (WPs):

• The aim of WP1 is to map the relationship between GS and clinical outcomes with EEG.

• The aim of WP2 is to translate GS assessment and modulation to bedside.

• The aim of WP3 is to modulate GS to improve rehabilitation outcomes. ;

Related Conditions & MeSH terms

• Stroke

• NCT number: NCT05830617
• Study type: Interventional
• Source: IRCCS San Camillo, Venezia, Italy
• Contact: Giorgio Arcara
• Phone: 0412207594
• Email: giorgio.arcara@hsancamillo.it
• Status: Recruiting
• Phase: N/A
• Start date: March 23, 2021
• Completion date: March 23, 2024