Stroke Clinical Trial
Official title:
Multisite Transcranial Direct Current Stimulation Targeting Motor Network by Mapping Electric Fields With Task-based fMRI to Promote Hand Function Recovery After Stroke
NCT number | NCT05638464 |
Other study ID # | 2018.661 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | August 13, 2021 |
Est. completion date | December 2023 |
A novel multisite high definition tDCS (HD-tDCS) in healthy people showed that such network-targeted stimulation could enhance motor excitability beyond traditional stimulation which targeting only one region. It showed that the excitability following multisite HD-tDCS was more than double the increase following conventional tDCS. To consider the various lesion site of different stroke survivors. The electrode placements based on personalized lesion profiles and anatomical features can be determined using finite element modeling, with lesion profiles generated from fMRI and advanced algorithms calculating the current density to maximize the modulation effect. Combining motor network interaction and the new multisite electrode montage may further provide a potential to facilitate stroke recovery.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | December 2023 |
Est. primary completion date | December 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - first-ever stroke, the duration after stroke exceeds 12 months; - mild to moderate upper extremity motor function deficit, determined by the Fugl-meyer assessment of upper extremity (FMAUE) scores between 15 and 53; - detectable voluntary muscle sEMG signal from flexor digitorum (FD) and extensor digitorum (ED); - scored below 3 in the Modified Ashworh Score (MAS) of FD and ED; - sufficient cognitive function to follow the assessment and training instructions, determined by Mini Mental State Examination score of more than 21. Exclusion Criteria: - history of epilepsy, or any other contradictions of brain stimulation; - severe joint contracture of elbow or shoulder, or pain induced by any other neurological, neuromuscular, and orthopedic diseases. |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Department of Biomedical Engineering, The Chinese University of Hong Kong | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Action Research Arm Test | The ARAT is a 19-item measure divided into 4 sub-tests (grasp, grip, pinch, and gross arm movement) to assess upper limb functioning | 6-month after intervention | |
Primary | Fugl-Meyer Assessment Upper Extremity | It is used to evaluate and measure upper-limb recovery in post-stroke hemiplegic patients, and items are scored on a 3-point ordinal scale | 6-month after intervention | |
Primary | Electroencephalography (EEG) and Electromyography (EMG) | It is used to investigate the changes in corticomuscular coherence for studying connectivity between the brainwave using EEG and the affected hand muscles using EMG. In addition, EMG will be used to detect muscle activation change and muscle co-contraction pattern alteration. | 6-month after intervention | |
Primary | Magnetic Resonance Imaging (MRI) | It is used to identify neural correlates of stimulation-induced behavioral gains for investigating tDCS-induced changes in brain activations | 6-month after intervention |
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