OPTIMIZATION of ADVANCED MR SEQUENCES

Stroke Clinical Trial

— OPT-IRM  

Official title:

OPTIMIZATION of AVANCED MR SEQUENCES for BRAIN STUDIES in VOLUNTEERS (HEALTHY and PATIENTS)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05618990
• Other study ID #: D19-P005
• Status: Recruiting
• Start date: November 5, 2019
• Est. completion date: December 5, 2025

Study information

• Verified date: September 2022
• Source: Centre Hospitalier St Anne
• Contact: Khaoussou SYLLA
• Phone: 01 45 65 76 78
• Email: k.sylla[@]ghu-paris.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to research in clinical and cognitive neuroscience.

Description:

Primary goal : Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences. Secondary goals 1. Perform acquisitions to validate the feasibility of research MR protocols (pilot subjects) 2. reproducibility studies

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 300
• Est. completion date: December 5, 2025
• Est. primary completion date: November 5, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 ans
• Covered by social security
• For women in age of procreation, under efficient contraception
• Written consent

Exclusion Criteria:

• Any MR contraindication
• Claustrophobia
• Pregnancy
• Under judiciary protection

Related Conditions & MeSH terms

• Brain Tumor
• Mental Disorders
• MRI
• Neurosciences
• Stroke

Locations

Country	Name	City	State
France	OPPENHEIM Catherine	Paris

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier St Anne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MR sequences optimization	Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences. Outcome measures depend on each pulse optimized sequence (signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).	72 months
Secondary	Reproducibility studies	Reproducibility studies (quantitative parameters, effect of denoising ...). Outcome measures depend on each pulse optimized sequence (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).	72 months
Secondary	Pilot studies	Feasibility studies in cognitive neurosciences. Outcome measures depend on each MR protocol (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).	72 months