Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Stroke

Stroke Clinical Trial

Official title:

Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Ischemic Stroke

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05305625
• Other study ID #: XYFY2022-KL026
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 1, 2022
• Est. completion date: May 1, 2023

Study information

• Verified date: January 2022
• Source: The Affiliated Hospital of Xuzhou Medical University
• Contact: Yu Lu, MD
• Phone: 0086-18151865060
• Email: Yulumed[@]163.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Investigators aimed to investigate the changes of glymphatic function after remote ischemic postcondioning treatment in acute ischemic stroke .

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: May 1, 2023
• Est. primary completion date: May 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• The patient was 18-80 years old;

• The NIHSS score was = 25 and NIHSS > 5,Glasgow coma score = 8;

• The patients were diagnosed as anterior circulation cerebral infarction and could start remote ischemic postcondioning within 24 hours after onset

• Normal to random time within 24 hours

• Written informed consent signed by patients or their families

Exclusion criteria:

• patients receiving thrombolysis or endovascular therapy;

• modified Rankin scale (mRS) score = 2 before this attack;

• other intracranial lesions, such as cerebral hemorrhage, cerebral venous disease, severe subclavian artery stenosis and other diseases involving the brain;

• Arterial blood pressure = 90/60mmHg or = 180/100mmHg after treatment.

Related Conditions & MeSH terms

• Stroke

Intervention

Procedure:
• remote ischemic postcondioning
remote ischemic postcondioning twice daily, for three consecutive days,the upper arm of the lighter paralyzed side was pressurized to 200mmHg, pressurized 5min and relaxed for 5 minutes for 4 cycles as a complete remote ischemic postcondioning

Drug:
• standard therapy
received standardized treatment

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
The Affiliated Hospital of Xuzhou Medical University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes of glial lymphatic system	The size of the vascular spaces was assessed by brain magnetic resonance of ischemic postcondioning group and standard therapy group	from baseline to 3 day
Secondary	Differential expression pattern of differential proteins	Differential expression pattern of differential proteins in blood of patients with remote ischemic postcondioning group and standard therapy group	from baseline to 3 day