Stroke Clinical Trial
— DISOWNOfficial title:
This is Not my Body: the Disrupted Bodily Self of Neurological Patients
Verified date | July 2021 |
Source | University of Geneva, Switzerland |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Some pathological clinical conditions can strongly perturb the link between body and self. One disorder of body representation is the feeling of disownership over body parts, experienced by neurological patients usually after a stroke affecting the right hemisphere. Body disownership and more complex somatoparaphrenic delusions are described as rare in the scientific literature and no clear consensus about their features, brain correlates and recovery mechanisms are on record. Recently, the investigators have discovered that using new sensitive tools it is possible to unveil the presence of covert disownership deficits in patients, who seemed completely unimpaired at the standard assessment. Within a bigger exploratory study of this covert disownership in stroke patients, the aim is to implement a proof-of-concept rehabilitation study, using a multisensory stimulation paradigm, with the hypothesis that a positive remission of disownership will be found and that this treatment can influence both the implicit and explicit features of disownership.
Status | Not yet recruiting |
Enrollment | 5 |
Est. completion date | December 2023 |
Est. primary completion date | December 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 85 Years |
Eligibility | Inclusion Criteria: - First neurological event, affecting the right hemisphere or the left hemisphere (stroke); - Structural images of the brain lesion available (magnetic resonance or tomographic scans); - Full somato-sensory deficit affecting the left hand; - Good (or corrected) visual acuity; - Good proficiency in French; - Right-handed Exclusion Criteria: - Failure to meet the inclusion criteria ; - Presence of general cognitive deficits and/or suspicious of possible cognitive deficits; - Presence of difficulty in task's comprehension; - Impossibility to sustain a research session of at least 45minutes (e.g., attentional lability); - Precedent additional neurological disorder and/or current or precedent psychiatric disease. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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University of Geneva, Switzerland |
Aspell JE, Lenggenhager B, Blanke O. Multisensory Perception and Bodily Self-Consciousness: From Out-of-Body to Inside-Body Experience. In: Murray MM, Wallace MT, editors. The Neural Bases of Multisensory Processes. Boca Raton (FL): CRC Press/Taylor & Francis; 2012. Chapter 24. — View Citation
Bolognini N, Ronchi R, Casati C, Fortis P, Vallar G. Multisensory remission of somatoparaphrenic delusion: My hand is back! Neurol Clin Pract. 2014 Jun;4(3):216-225. doi: 10.1212/CPJ.0000000000000033. — View Citation
Romano D, Maravita A. The dynamic nature of the sense of ownership after brain injury. Clues from asomatognosia and somatoparaphrenia. Neuropsychologia. 2019 Sep;132:107119. doi: 10.1016/j.neuropsychologia.2019.107119. Epub 2019 Jun 11. — View Citation
Ronchi R, Bassolino M, Viceic D, Bellmann A, Vuadens P, Blanke O, Vallar G. Disownership of body parts as revealed by a visual scale evaluation. An observational study. Neuropsychologia. 2020 Feb 17;138:107337. doi: 10.1016/j.neuropsychologia.2020.107337. Epub 2020 Jan 7. — View Citation
Vallar G, Ronchi R. Somatoparaphrenia: a body delusion. A review of the neuropsychological literature. Exp Brain Res. 2009 Jan;192(3):533-51. doi: 10.1007/s00221-008-1562-y. Epub 2008 Sep 24. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in the visual analog scale (VAS) score about covert disonwership of the left hand | Just before and after each stimulation, we will use a VAS to monitor if the patients modify their sense of body (dis)ownership. Range: 0-21cm, 0= worst score (feeling of disownership), 21= better score (feeling of ownership) | from Baseline to 15 minutes | |
Primary | Effect size of the implicit association test (IAT) | Just before and after each stimulation, we will use the experimental body IAT to monitor if patients modify their implicit awareness of the body. We will use the effect size score, which combine the reaction times of the congruent and incongruent categories, plus the errors made, into a unique score following a standard previously published algorithm. | from Baseline to 1 hour |
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