Stroke Clinical Trial
Official title:
Relationship Between Baseline Serum Albumin Level and Cognitive Impariment in Mild Acute Ischemic Stroke
This registration enrolled patients with acute ischemic stroke within 72 hours after stroke ictus. Patients was identified as first-ever stroke based on past medical histrory. Admission CT was conducted to exclude hemorrhagic stroke, but not those bleeding transformation after ischemia injury. Baseline characteristics, including demographics, vascular risk factors, lab tests and neuroimagings were collected. Patients were followed up for cognitive assessments.
This is a perspective stroke registry cohort study. Stroke patients were included if ：(1)
acute first-ever ischemic stroke and admitted within 72 hours after onset; (2) clinical
stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging
(DW-MRI), those with isolated posterior circulations infarcts were exclude ; (3) presented
with mild stroke severity ( admission NIHSS score ≤5); (4) age between 40 and 80 years.
Clinical data including demographic characteristics, risk factors, and baseline NIHSS score
were assessed and collected using a standardized table by experienced neurologists. Lab tests
were performed with fasting venous blood samples within 18 hours of admission.
Patients were followed up for 6 months. The cognitive functions were assessed using the
Chinese version of Montreal Cognitive Assessment (MoCA).
Contributing factors to post-stroke cognitive impariment (PSCI) were determined by comparing
clinical data between PSCI and non-PSCI groups. All potential confounders were introduced
into the multivariate regression models.
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