White Matter Integrity According to BDNF Genotype After Stroke

Stroke Clinical Trial

Official title:

Changes of White Matter Integrity According to BDNF Genotype During Motor Recovery After Stroke

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03647787
• Other study ID #: 2018-04-146
• Status: Completed
• Start date: May 25, 2018
• Est. completion date: April 5, 2019

Study information

• Verified date: September 2018
• Source: Samsung Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study was to investigate differential plastic changes of fractional anisotropy (FA) in the corticospinal tract (CST), the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv) and the corpus callosum (CC) from 2 weeks to 3 months after stroke according to BDNF genotype.

Description:

The aims of this study were to investigate plastic changes in the fractional anisotropy (FA) of three motor-related white matter fibers according to the BDNF genotype from 2 weeks to 3 months after stroke onset; one is a the majority of fibers from M1 to medullary oblongata (CST), another is the intrahemispheric connection from M1 to ventral premotor cortex (M1PMv), and the other is the interhemispheric connection between bilateral M1s (CC). There were also to investigate the relationships between motor impairment and tract-related FA of white matter tracts in each BDNF genotype

Recruitment information / eligibility

• Status: Completed
• Enrollment: 58
• Est. completion date: April 5, 2019
• Est. primary completion date: April 5, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• diagnosed with first-ever hemispheric ischemic infarction with damage to the supratentorial area confirmed by brain MRI within 2 weeks after stroke onset

Exclusion Criteria:

• any clinically significant or unstable medical disorder or neuropsychiatric comorbidity

Related Conditions & MeSH terms

• Stroke

Intervention

Other:
• observational study
This study is a longitudinal observational study

Locations

Country	Name	City	State
Korea, Republic of	Samsung Medical Center	Seoul	Gangnam-gu

Sponsors (1)

Lead Sponsor	Collaborator
Samsung Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fractional anisotropy	changes of fractional anisotropy (FA) in the corticospinal tract (CST)	2 weeks to 3 months after stroke onset
Secondary	Fractional anisotropy	changes of fractional anisotropy (FA) in the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv)	2 weeks to 3 months after stroke onset
Secondary	Fractional anisotropy	changes of fractional anisotropy (FA) in the corpus callosum (CC)	2 weeks to 3 months after stroke onset