Stroke Clinical Trial
Official title:
Role of Genetic Polymorphism in Neuroplasticity Involved in Dysphagia Recovery
The purpose of this study is to assess the association of genetic polymorphism such as the Brain-derived Neurotrophic factor (BDNF), in neurogenic dysphagia in those with brain lesion.
Neurogenic dysphagia attributable to acquired brain lesions, such as after stroke and after
traumatic brain injury, are one of leading causes of chronic disability world widely and it
is expected to substantially increase over the next two decades. Among various sequalae,
dysphagia can be observed in about 40% -60% of post-stroke patients and 20% -30% of them
might suffer from recurrent aspiration pneumonia and may inhibit recovery and can even lead
to death. Recovery after brain lesions can be explained by specific molecular events. It is
proven that Genetic polymorphisms associated with impaired neural repair or plasticity might
reduce recovery from stroke. Not only for the motor recovery, but genetic polymorphism is
also crucial for the recovery of swallowing after stroke, however, only limited amount of
studies are available. Therefore, it is urgent to determine whether the recovery of
swallowing disorders after stroke is affected by the inherent polymorphism of the patient,
whether the degree of recovery and brain plasticity associated with swallowing depend on the
gene characteristics and polymorphism of the patient and whether recovery in swallowing
parallel to the recovery observed in other functional areas (ie. hand recovery, truncal
control recovery, ADL recovery).
Based on the results of this study, results will be expected to help provide genetically
tailored diagnosis and prognostication according to the gene polymorphism of the patient.
Optimized treatment of the patient is expected to contribute to prevention of respiratory
complications and improve functional outcome related to swallowing after stroke.
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