Changes in Sensitivity, Taste and Smell in Stroke Patients — 5S  

Stroke Clinical Trial

Official title: Changes in Sensitivity of Swallowing-relevant Structures, Taste and Smell in Stroke Patients

Status Recruiting

Clinical Trial Summary

This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients. Younger (<60 years) and older (>60 years) volunteers will serve as control.

Clinical Trial Description

Stroke is the second leading cause of death. At least 50% of stroke patients develop dysphagia, leading to aspiration pneumonia, which is the main cause of death in stroke [2].

It is assumed that normal sensitivity is vital for aspiration-free swallowing and for the triggering of the swallowing reflex.

Ali et al. demonstrated aspiration-free swallowing in healthy volunteers who underwent local anaesthesia of oral and pharyngeal structures [1]. Power et al. showed a reduced sensitivity of pharyngeal structures in stroke patients prone to aspiration [3].

By combining measuring sensitivity and flexible endoscopic swallowing studies, this study further investigates the role of sensitivity in swallowing Neuropsychological deficits of swallowing, such as swallowing apraxia or buccal hemineglect, is assessed by neuropsychological testing.

Additionally, there is no systematic research investigating the change in smell and taste in correlation with changes in stroke patients ;

Related Conditions & MeSH terms

• Dysphagia
• Stroke

• NCT number: NCT03240965
• Study type: Observational
• Source: University of Giessen
• Contact: Tobias Braun, M.D.
• Phone: +49(0)-641-985
• Email: tobias.braun@neuro.med.uni-giessen.de
• Status: Recruiting
• Start date: October 1, 2017
• Completion date: December 2026