Stroke Clinical Trial
Official title:
Serum BDNF Role as a Biomarker for Stroke Rehabilitation
This study aims to develop the quantitative biomarker to establish the individualized strategy in stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) acts on certain neurons of the central nervous system (CNS) helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. BDNF in CNS can be assessed by analysing serum BDNF. The final objective of this study is to demonstrate a role of biomarker of BDNF in stroke rehabilitation to establish the individualized strategy.
Serum BDNF, proBDNF and MMP-9 in all participants will be measured before and after the
comprehensive inpatient rehabilitation during subacute stroke phase. At 3 months after stroke
onset, serum BDNF, proBDNF and MMP-9 will also be measured.
In addition, motor impairment with Fugl-Meyer assessement will be assessed at same time
points with serum analysis.
We will compare potential serum biomarkers with motor impairment in stroke patients
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