Stroke Clinical Trial
Official title:
Randomised Controlled Prospective Trial of Early Administration of Aspirin After Systemic Thrombolysis in Acute Ischemic Stroke
The aim of this study is to determine whether early administration of aspirin in acute ischemic stroke patients treated with systemic thrombolysis is safe and can improve outcomes due to decreasing the number of early rethromboses.
According to the current guidelines (European Stroke Organisation, 2009; American Heart
Association-American Stroke Association, 2013) on the systemic thrombolysis in ischemic
stroke patients it is recommended (class C) to start antithrombotic therapy (including
antiplatelets and anticoagulants) when 24 hours go after alteplase (rtPA, recombinant tissue
plasminogen activator) administration. Meanwhile rtPA has wery short lifetime in blood (T1/2
4-6 minutes). Some retrospective studies have found that early administration of
antithrombotics (8-16 hours) after systemic thrombolysis can improve functional outcome and
does not increase the risk of haemorrhage.
The investigators suggest a controlled prospective trial to recognise risks and benefits of
early administration of aspirin (in 12 hours) after rtPA therapy in patients with acute
ischemic stroke.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
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