Stroke Clinical Trial
Official title:
Comparing the Behavior of the Cardiac Autonomic Regulation System During 24h in Patient Post Stroke and Controls
By Investigating the heart rate variability (HRV) of 15 patients after stroke and compare it
to the HRV of 15 orthopedic patients, the investigators hope to achieve 3 main goals:
1. To describe the 24-hour circadian rhythm of heart rate among patients after stroke in the
sub-acute phase during 3 days. 2. To examine the differences in the circadian rhythm of
heart rate along 3 days between patients after stroke in the sub-acute phase and control
group matched by age and gender. 3. To describe the reaction and examine the differences in
reactions of the heart autonomic system during rest, paced breathing and activity in both
groups- stoke and control.
The HRV will be monitored by Polar watch and the activity will be measured by accelerometer,
both will be attached to the patients at the beginning of the trial and will stay on them
for 3 whole days.
Background: Evaluating the autonomic system is conducting, among others, by comparing the
relationships between the two sub-systems that assembler it: the sympathetic and the
parasympathetic systems. In normal conditions, there is balance between both systems which
reflects in a highly dynamic heart rate and heart rate variability. As part of the brain
injury after stroke, the autonomic system is also damaged. The heart rate variability is
decreased and the 24-hour circadian rhythm of heart rate changes.
Purposes of the research: 1. To describe the 24-hour circadian rhythm of heart rate among
patients after stroke in the sub-acute phase during 3 days. 2. To examine the differences in
the circadian rhythm of heart rate along 3 days between patients after stroke in the
sub-acute phase and control group matched by age and gender. 3. To describe the reaction and
examine the differences in reactions of the heart autonomic system during rest, paced
breathing and activity in both groups- stoke and control.
Methods:
Population: 15 patients after cerebrovascular accident (CVA), 1-3 weeks after the stroke.
The patients will be hospitalized in the neurology department at the geriatric "Beit-Rivka"
hospital. The control group will be 15 patients from the orthopedic department of the
hospital' matching by age and gender. Tools: monitoring heart rate and heart rate
variability by Polar watch (Polar RS800CX heart rate monitor). Monitoring activity will
measure by accelerometer. Methods: after attaching to RS800CX watch, each participant will
complete two tests: the response of heart rate to deep breathing and the response of heart
rate variability to prolonged hand grip. The department nurse will be asked to answer a
questionnaire regarding autonomic functions and the examiner will asses the functional
independence of the participant by the "Functional Independence Measure" (FIM). In the
research group will be additional assessments regarding the motor function by the "Stroke
Activity Scale" and the "Scandinavian Stroke Scale". The watch and the accelerometer will
stay on the participant for 3 day (72 hours) and the records regarding the daily activity
such as meals, sleep, and all kind of treatments will be taken from the department's diary.
At the end of three days, the data will be collected and analyzed on computer software.
;
Observational Model: Case Control, Time Perspective: Prospective
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