Stroke Clinical Trial
Official title:
Vanderbilt Assessment of Multi-modal MRI in Patients At-Risk for Stroke With Intracranial Stenosis
The overall aim of this work is to assess the relationship between stroke risk and hemodynamic compensation strategies, as measured using a novel 3.0 Tesla MRI protocol, in patients with symptomatic intracranial (IC) steno-occlusive disease. Recent studies have shown high two-year ischemic stroke rates in symptomatic patients with IC arterial stenosis. Therapy for IC stenosis patients includes revascularization with angioplasty, IC stenting, or bypass, however identification of patients most likely to benefit from these more aggressive interventions, rather than medical management alone, has been problematic. Accurate measurements of hemodynamic compromise are likely required to better define stroke risk and guide treatment decisions. Specifically, in IC stenosis patients with compromised cerebral perfusion pressure (CPP), the extent of hemodynamic compromise reflects the autoregulatory capacity of vasculature to increase arterial cerebral blood volume (aCBV) and/or develop collaterals to supplement cerebral blood flow (CBF). The prevalence of CBF collateralization and aCBV autoregulation has been hypothesized to correlate uniquely with stroke risk, however the extent of this correlation has been debated. The critical barrier to stratifying stroke risk rests with a lack of (i) methodology for measuring multiple hemodynamic factors with high specificity and (ii) noninvasive approaches capable of monitoring longitudinal progression of impairment. The investigators have demonstrated the clinical utility of relatively new, noninvasive MRI approaches for assessing cerebrovascular reactivity (CVR), aCBV, and collateral CBF. The investigators hypothesize that stroke risk can be more completely evinced from collective measurements of these parameters. Therefore, the investigators propose to implement a novel, validated hemodynamic MRI protocol to assess tissue-level impairment and compensation strategies in patients with IC stenosis. Using a collective approach combining measurements of collateral CBF, aCBV and CVR in multiple brain regions, in conjunction with a statistical model incorporating the above variables as possible prognostic factors, the investigators will quantify the extent to which two-year stroke risk is associated with hemodynamic compensation mechanisms. The noninvasive and multi-faceted scope of this investigation is intended to expand the diagnostic stroke infrastructure and elucidate new hemodynamic prognostic indicators of stroke in this high-risk population.
The overall aim of this work is to assess the relationship between stroke risk and
hemodynamic compensation strategies, as measured using a novel 3.0 Tesla (T) MRI protocol, in
patients with symptomatic intracranial (IC) steno-occlusive disease. Recent studies have
shown high two-year ischemic stroke rates of approximately 20% in symptomatic IC stenosis
patients. Aggressive therapy for IC stenosis patients includes revascularization with
angioplasty, IC stenting, or bypass, however identification of patients most likely to
benefit from these more aggressive interventions, rather than medical management alone, has
been problematic. Accurate measurements of hemodynamic compromise are likely required to
better define stroke risk and guide treatment decisions. Specifically, in IC stenosis
patients with compromised cerebral perfusion pressure (CPP), the extent of hemodynamic
compromise reflects the autoregulatory capacity of vasculature to increase arterial cerebral
blood volume (aCBV) and/or develop collaterals to supplement cerebral blood flow (CBF). The
prevalence of CBF collateralization and aCBV autoregulation has been hypothesized to
correlate uniquely with stroke risk, however the extent of this correlation is debated.
The critical barrier to stratifying stroke risk rests with a lack of (i) methodology for
measuring multiple hemodynamic factors with high specificity and (ii) noninvasive approaches
capable of monitoring longitudinal progression of impairment. The investigators have
demonstrated the clinical utility of relatively new, noninvasive MRI approaches for assessing
cerebrovascular reactivity (CVR), aCBV, and collateral CBF. These approaches have been
optimized and feasibility assessed in healthy volunteers or isolated clinical studies,
however comparatively little information is available regarding the relationship between
these collective measures and stroke risk. Therefore, the investigators propose to complement
established angiographic and structural imaging with more novel, validated hemodynamic
measurements to assess tissue-level impairment and compensation strategies in patients with
IC stenosis. Using a collective approach combining measurements of collateral CBF, aCBV and
CVR in multiple brain regions, in conjunction with a statistical model incorporating the
above parameters as possible prognostic factors, the investigators will quantify the extent
to which two-year stroke risk is associated with hemodynamic compensation mechanisms in a
population of symptomatic IC stenosis patients. The noninvasive and multi-faceted scope of
this investigation is intended to expand the diagnostic stroke infrastructure and elucidate
new hemodynamic prognostic indicators of stroke in this high-risk population.
Hypothesis (1). Changes in collateral CBF with hypercarbic stimulation positively correlate
with two-year stroke incidence in symptomatic IC stenosis patients.
Aim (1). By separately magnetically labeling blood water in different feeding arteries (8),
the investigators will use a tested vessel-selective arterial spin labeling (VS-ASL) approach
and a calculated perfusion asymmetry index to noninvasively assess changes in collateral CBF
patterns in patients with IC stenosis. IC stenosis (n=90) patients will be monitored for two
years during which their known stroke incidence is 20%. Stroke incidence will be recorded and
separate correlations between perfusion asymmetry and stroke risk will be assessed.
Hypothesis (2). Regionally reduced CVR, indicative of vascular steal phenomena, and elevated
aCBV, will positively correlate with two-year stroke incidence in symptomatic IC stenosis
patients.
Aim (2). CVR, as measured using the blood oxygenation level-dependent (BOLD) MRI signal
change in response to hypercarbia, will be used to assess cerebrovascular reserve. The inflow
vascular-space-occupancy with dynamic subtraction (iVASO-DS) approach, which we have
developed and demonstrated in patients, will be applied to assess baseline aCBV. For the same
patients as in Aim 1, CVR dynamics and aCBV will be statistically assessed for unique
relationships with two-year stroke incidence.
Hypothesis (3). Collateral CBF, autoregulatory aCBV, and CVR will correlate unequally with
two-year stroke incidence, the extent of which can be quantified using a multi-component
prediction model.
Aim (3). The investigators will build a statistical prediction model, using collateral CBF,
aCBV and CVR as prognostic factors, to quantify the extent to which trends in the above
parameters collectively contribute to stroke risk. The high two-year stroke rate (20%) and
large number of admitted patients with symptomatic IC stenosis, will enable this study to
detect hypothesized group differences with high statistical power.
This work is an extension of recent methodological work whereby a novel, collective
compensatory hemodynamic protocol is applied to a specific clinical population to understand
prognostic potential. Successful completion should provide new information on tissue
hemodynamics and stroke risk in patients that can be used to guide management decisions,
ultimately reducing stroke incidence in this high-risk population.
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