Stroke Clinical Trial
Official title:
Late LTP-like Plasticity Effects of tDCS in Subacute Stroke Patients
Rationale: About 80% of stroke patients suffer motor impairments, but current therapies have
limited effects on motor recovery. Therefore, investigating new potential therapeutic
approaches is crucial. Transcranial Direct Current Stimulation (tDCS) is a form of
non-invasive electrical stimulation where a weak current is applied through electrodes over
the scalp. This stimulation is known to (1) induce changes in neuronal excitability -which
can last up to one day with late LTP-like plasticity protocols in a polarity and
site-specific manner, and (2) facilitate motor learning and stroke recovery. So far, several
pilot studies have reported beneficial results from tDCS in both subacute and chronic stroke
patients, but it's still unclear how tDCS should be repeated over multiple days to optimally
enhance recovery and training effects. Using a late LTP-like plasticity protocol could
increase effectiveness of standard clinical care rehabilitation sessions and thus enhance the
effects of rehabilitation. Therefore, the investigators want to investigate how late LTP-like
plasticity tDCS affects rehabilitation in subacute stroke patients. The outcome of this study
can provide important guidelines on effective motor therapy during stroke rehabilitation.
Objective: Identify the effect of late LTP-like plasticity on motor rehabilitation during the
subacute phase after stroke.
Study design: Double-blinded, randomized between-subjects trials. Study population: Subacute
stroke patients. Main study parameters/endpoints: The primary outcome measure is the upper
limb motor function during the subacute phase after stroke.
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